Tnfsf12 MGI Mouse Gene Detail - MGI:1196259 - tumor necrosis factor (ligand) superfamily, member 12

Symbol

Tnfsf12
Name

tumor necrosis factor (ligand) superfamily, member 12
Synonyms

APO3L, DR3L, Tweak

Feature Type

protein coding gene
IDs

MGI:1196259
NCBI Gene: 21944
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:69577076-69586675 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.86 cM, cytoband B4
Mapping Data

2 experiments

SNPs within 2kb

253 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196259	protein coding gene	Chr11:69577066-69586924 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018550	protein coding gene	Chr11:70145262-70155097 (-)
A/J	MGP_AJ_G0018518	protein coding gene	Chr11:67503199-67512767 (-)
AKR/J	MGP_AKRJ_G0018487	protein coding gene	Chr11:69512943-69524360 (-)
BALB/cJ	MGP_BALBcJ_G0018490	protein coding gene	Chr11:67812625-67822599 (-)
C3H/HeJ	MGP_C3HHeJ_G0018303	protein coding gene	Chr11:69544728-69556287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018941	protein coding gene	Chr11:72266316-72278806 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016586	protein coding gene	Chr11:64422038-64431148 (-)
CAST/EiJ	MGP_CASTEiJ_G0017858	protein coding gene	Chr11:69786029-69797345 (-)
CBA/J	MGP_CBAJ_G0018276	protein coding gene	Chr11:75502674-75513506 (-)
DBA/2J	MGP_DBA2J_G0018385	protein coding gene	Chr11:67085665-67097038 (-)
FVB/NJ	MGP_FVBNJ_G0018375	protein coding gene	Chr11:66728972-66739425 (-)
LP/J	MGP_LPJ_G0018455	protein coding gene	Chr11:70713825-70723342 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018398	protein coding gene	Chr11:76093218-76104902 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018983	protein coding gene	Chr11:69774569-69785553 (-)
PWK/PhJ	MGP_PWKPhJ_G0017632	protein coding gene	Chr11:67735545-67745484 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017422	protein coding gene	Chr11:69594511-69604036 (-)
WSB/EiJ	MGP_WSBEiJ_G0017912	protein coding gene	Chr11:69446870-69458155 (-)

Human Ortholog

TNFSF12, TNF superfamily member 12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFSF12, TNF superfamily member 12
Synonyms

APO3L, DR3LG, TNLG4A, TWEAK
Links

HGNC:11927

NCBI Gene ID: 8742

neXtProt AC: NX_O43508

UniProt: O43508
Chr Location

17p13.1; chr17:7548508-7557890 (+) GRCh38

Human Ortholog

TNFSF12-TNFSF13, TNFSF12-TNFSF13 readthrough
Synonyms

TWE-PRIL
Links

HGNC:33537

NCBI Gene ID: 407977

neXtProt AC: NX_O43508
Chr Location

17p13.1; chr17:7549058-7561601 (+) GRCh38

MGI Vertebrate Homology

Tnfsf12 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFSF12, TNFSF12-TNFSF13
Gene Tree

Tnfsf12

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

8
Transgenic

1
Genomic Mutations

2 involving Tnfsf12
Incidental Mutations

APF
Find Mice (IMSR)

105 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have increased numbers of natural killer cells, particulalry in secondary lymph organs. They display an enhanced inflammatory response, increased susceptibility to lipopolysaccharide, and increased tumor resistance.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

35
cDNA Data

10
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tnfsf12

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All Sequences

38
RefSeq

2
UniProt

4
CCDS

CCDS24907.1

Ensembl

ENSMUSG00000097328 (Evidence)
NCBI Gene

21944

			Length	Strain/Species	Flank
genomic	ENSMUSG00000097328	Ensembl Gene Model \| MGI Sequence Detail	9600	C57BL/6J	± kb
transcript	ENSMUST00000181810	Ensembl \| MGI Sequence Detail	1435	Not Applicable
polypeptide	ENSMUSP00000137972	Ensembl \| MGI Sequence Detail	249	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016487 tumor necrosis factor ligand superfamily member 12

(term hierarchy)
InterPro Domains

IPR051748 Tumor Necrosis Factor Ligand Superfamily

IPR006052 Tumour necrosis factor domain

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

O54907 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 2

Summaries

All 113

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 42
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:343504 Guerrero-Hue M, et al., Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury. Biomed Pharmacother. 2023 Dec 31;169:115925

TSS for Tnfsf12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108801	Chr11:69586774-69586785 (-)	-105 bp
Tssr108800	Chr11:69586707-69586726 (-)	-42 bp
Tssr108799	Chr11:69586628-69586698 (-)	12 bp
Tssr108798	Chr11:69586579-69586611 (-)	80 bp
Tssr108797	Chr11:69586465-69586539 (-)	173 bp
Tssr108796	Chr11:69584477-69584493 (-)	2,190 bp
Tssr108795	Chr11:69584363-69584378 (-)	2,304 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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