R3hcc1l MGI Mouse Gene Detail - MGI:1196316 - R3H domain and coiled-coil containing 1 like

Symbol

R3hcc1l
Name

R3H domain and coiled-coil containing 1 like
Synonyms

1700036B12Rik, D19Ertd386e

Feature Type

protein coding gene
IDs

MGI:1196316
NCBI Gene: 52013
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:42507198-42580782 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 36.47 cM
Mapping Data

3 experiments

SNPs within 2kb

1667 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196316	protein coding gene	Chr19:42506419-42580782 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025146	protein coding gene	Chr19:41854303-41930776 (+)
A/J	MGP_AJ_G0025123	protein coding gene	Chr19:39851004-39921093 (+)
AKR/J	MGP_AKRJ_G0025091	protein coding gene	Chr19:41141585-41211732 (+)
BALB/cJ	MGP_BALBcJ_G0025117	protein coding gene	Chr19:39908251-39979113 (+)
C3H/HeJ	MGP_C3HHeJ_G0024877	protein coding gene	Chr19:41297572-41367125 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025560	protein coding gene	Chr19:42925741-43000934 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022974	protein coding gene	Chr19:39200289-39273720 (+)
CAST/EiJ	MGP_CASTEiJ_G0024342	protein coding gene	Chr19:40981464-41065822 (+)
CBA/J	MGP_CBAJ_G0024857	protein coding gene	Chr19:45009234-45083253 (+)
DBA/2J	MGP_DBA2J_G0024989	protein coding gene	Chr19:39690759-39761410 (+)
FVB/NJ	MGP_FVBNJ_G0024950	protein coding gene	Chr19:39466866-39536106 (+)
LP/J	MGP_LPJ_G0025075	protein coding gene	Chr19:41843613-41914075 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024981	protein coding gene	Chr19:44624780-44702293 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025618	protein coding gene	Chr19:41200051-41277175 (+)
PWK/PhJ	MGP_PWKPhJ_G0024091	protein coding gene	Chr19:39587831-39662507 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023895	protein coding gene	Chr19:39939877-40016889 (+)
WSB/EiJ	MGP_WSBEiJ_G0024412	protein coding gene	Chr19:41345543-41416445 (+)

Human Ortholog

R3HCC1L, R3H domain and coiled-coil containing 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

R3HCC1L, R3H domain and coiled-coil containing 1 like
Synonyms

C10orf28, GIDRP86, GIDRP88, PSORT
Links

HGNC:23512

NCBI Gene ID: 27291

neXtProt AC: NX_Q7Z5L2

UniProt: Q7Z5L2
Chr Location

10q24.2; chr10:98134624-98244897 (+) GRCh38

MGI Vertebrate Homology

R3hcc1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: R3HCC1L
Gene Tree

R3hcc1l

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

1
Gene trapped

24
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

69 strains or lines available

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All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

31
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase r3hcc1l

ZFIN r3hcc1l

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All Sequences

50
RefSeq

4
UniProt

3
CCDS

CCDS29829.1

Ensembl

ENSMUSG00000025184 (Evidence)
NCBI Gene

52013

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025184	Ensembl Gene Model \| MGI Sequence Detail	73585	C57BL/6J	± kb
transcript	ENSMUST00000026188	Ensembl \| MGI Sequence Detail	4112	Not Applicable
polypeptide	ENSMUSP00000026188	Ensembl \| MGI Sequence Detail	775	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007974 coiled-coil domain-containing protein R3HCC1L

(term hierarchy)
InterPro Domains

IPR039884 Coiled-coil domain-containing protein R3HC1/R3HCL

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 5

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MGI:1920569, MGI:2147546

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for R3hcc1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156499	Chr19:42507209-42507233 (+)	23 bp
Tssr156500	Chr19:42507234-42507269 (+)	54 bp
Tssr156501	Chr19:42513303-42513305 (+)	6,106 bp
Tssr156502	Chr19:42519745-42519753 (+)	12,551 bp
Tssr156504	Chr19:42579962-42579968 (+)	72,767 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24