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Arhgap6 Gene Detail
Summary
  • Symbol
    Arhgap6
  • Name
    Rho GTPase activating protein 6
  • Synonyms
    RhoGAPX-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196332
    NCBI Gene: 11856
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:167578095-168087431 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 78.77 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8725 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196332
 protein coding gene ChrX:167578091-168087436 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036275
 protein coding gene ChrX:167001653-167521738 (+)
A/J MGP_AJ_G0036245
 protein coding gene ChrX:166131150-166635217 (+)
AKR/J MGP_AKRJ_G0036174
 protein coding gene ChrX:171453277-171972138 (+)
BALB/cJ MGP_BALBcJ_G0036239
 protein coding gene ChrX:164094309-164601691 (+)
C3H/HeJ MGP_C3HHeJ_G0035946
 protein coding gene ChrX:167310955-167833201 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036762
 protein coding gene ChrX:171848108-172365361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033582
 protein coding gene ChrX:156853276-157352164 (+)
CAST/EiJ MGP_CASTEiJ_G0035233
 protein coding gene ChrX:146172821-146693456 (+)
CBA/J MGP_CBAJ_G0035920
 protein coding gene ChrX:176848942-177373227 (+)
DBA/2J MGP_DBA2J_G0036086
 protein coding gene ChrX:164895499-165410470 (+)
FVB/NJ MGP_FVBNJ_G0036018
 protein coding gene ChrX:164036932-164538838 (+)
LP/J MGP_LPJ_G0036171
 protein coding gene ChrX:168086607-168593425 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036050
 protein coding gene ChrX:185578524-186135209 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036801
 protein coding gene ChrX:166481731-167018465 (+)
PWK/PhJ MGP_PWKPhJ_G0034932
 protein coding gene ChrX:142897832-143392204 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034751
 protein coding gene ChrX:146755226-147290116 (+)
WSB/EiJ MGP_WSBEiJ_G0035369
 protein coding gene ChrX:164275014-164787849 (+)



Homology
more
  • Human Ortholog
    ARHGAP6, Rho GTPase activating protein 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP6, Rho GTPase activating protein 6
  • Synonyms
    RHOGAP6, RHOGAPX-1
  • Links
    NCBI Gene ID: 395
    neXtProt AC: NX_O43182
    UniProt: O43182

  • Chr Location
    Xp22.2; chrX:11117651-11665920 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arhgap6 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation do not exhibit any observable abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    27
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031355 Ensembl Gene Model | MGI Sequence Detail 509337 C57BL/6J ±  kb
    transcript ENSMUST00000033721 Ensembl | MGI Sequence Detail 5510 Not Applicable  
    polypeptide ENSMUSP00000033721 Ensembl | MGI Sequence Detail 987 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 4
      cDNA 27
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147898
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:44720 Schaefer L, et al., Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. Genomics. 1997 Dec 1;46(2):268-77
    • Latest
      J:222518 Yeung CY, et al., Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. PLoS One. 2014;9(9):e107036
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory