Hyal2 MGI Mouse Gene Detail - MGI:1196334 - hyaluronoglucosaminidase 2

Symbol

Hyal2
Name

hyaluronoglucosaminidase 2

Feature Type

protein coding gene
IDs

MGI:1196334
NCBI Gene: 15587
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:107445144-107449978 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 58.12 cM
Mapping Data

5 experiments

SNPs within 2kb

176 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196334	protein coding gene	Chr9:107445096-107449978 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035259	protein coding gene	Chr9:109443363-109448192 (+)
A/J	MGP_AJ_G0035238	protein coding gene	Chr9:105464911-105469740 (+)
AKR/J	MGP_AKRJ_G0035170	protein coding gene	Chr9:108097041-108101870 (+)
BALB/cJ	MGP_BALBcJ_G0035232	protein coding gene	Chr9:105134178-105139007 (+)
C3H/HeJ	MGP_C3HHeJ_G0034942	protein coding gene	Chr9:108496201-108501030 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035752	protein coding gene	Chr9:112434942-112439776 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032650	protein coding gene	Chr9:102894414-102899224 (+)
CAST/EiJ	MGP_CASTEiJ_G0034253	protein coding gene	Chr9:108428856-108433685 (+)
CBA/J	MGP_CBAJ_G0034910	protein coding gene	Chr9:116408783-116413617 (+)
DBA/2J	MGP_DBA2J_G0035071	protein coding gene	Chr9:104918618-104923452 (+)
FVB/NJ	MGP_FVBNJ_G0035019	protein coding gene	Chr9:103683459-103688288 (+)
LP/J	MGP_LPJ_G0035147	protein coding gene	Chr9:109649567-109654396 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035058	protein coding gene	Chr9:118021057-118025886 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035773	protein coding gene	Chr9:108368505-108373334 (+)
PWK/PhJ	MGP_PWKPhJ_G0033960	protein coding gene	Chr9:105238771-105243600 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033795	protein coding gene	Chr9:108424511-108429360 (+)
WSB/EiJ	MGP_WSBEiJ_G0034374	protein coding gene	Chr9:108251641-108256470 (+)

Human Ortholog

HYAL2, hyaluronidase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HYAL2, hyaluronidase 2
Synonyms

LUCA2
Links

HGNC:5321

NCBI Gene ID: 8692

neXtProt AC: NX_Q12891

UniProt: Q12891
Chr Location

3p21.31; chr3:50317790-50322782 (-) GRCh38

MGI Vertebrate Homology

Hyal2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HYAL2
Protein SuperFamily

Hyaluronidase
Gene Tree

Hyal2

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Phenotype Summary

35 phenotypes from 1 allele in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

3
Gene trapped

7
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit preweaning lethality, poor survival, craniofacial defects including submucosal cleft palate, and mild anemia. Incompletely penetrant features include cor triatriatum sinister and hearing loss.

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All GO Annotations

110
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

880
Tissues

131
cDNA Data

12
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hyal2

ZFIN hyal2a, hyal2b

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All Sequences

66
RefSeq

10
UniProt

7
CCDS

CCDS23496.1

Ensembl

ENSMUSG00000010047 (Evidence)
NCBI Gene

15587

			Length	Strain/Species	Flank
genomic	ENSMUSG00000010047	Ensembl Gene Model \| MGI Sequence Detail	4835	C57BL/6J	± kb
transcript	ENSMUST00000010191	Ensembl \| MGI Sequence Detail	1893	Not Applicable
polypeptide	ENSMUSP00000010191	Ensembl \| MGI Sequence Detail	473	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000008848 hyaluronidase-2

(term hierarchy)
EC

3.2.1.35
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR017853 Glycoside hydrolase superfamily

IPR018155 Hyaluronidase
GlyGen

O35632 5 sites, 4 N-linked glycans (4 sites)

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All nucleic 19

Genomic 2

cDNA 13

Primer pair 4

Microarray probesets 3

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MGI:2143004, MGI:2143243, MGI:2143332

Summaries

All 59

Developmental Gene Expression 11

Gene Ontology 15

Phenotypes 16
Earliest

J:50537 Strobl B, et al., Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998 Oct 15;53(2):214-9
Latest

J:346912 Huang H, et al., Hyaluronan degradation by HYAL2 is essential for odontoblastic differentiation and migration of mouse dental papilla cells. Matrix Biol. 2024 Mar 13;

TSS for Hyal2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86996	Chr9:107445102-107445140 (+)	-23 bp
Tssr86997	Chr9:107446311-107446334 (+)	1,179 bp
Tssr86998	Chr9:107446337-107446354 (+)	1,202 bp
Tssr86999	Chr9:107446355-107446383 (+)	1,225 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24