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Tnfaip3 Gene Detail
Summary
  • Symbol
    Tnfaip3
  • Name
    tumor necrosis factor, alpha-induced protein 3
  • Synonyms
    A20, Tnfip3, zinc finger protein A20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196377
    NCBI Gene: 21929
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:18876658-18891158 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 8.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196377
 protein coding gene Chr10:18876658-18891405 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017043
 protein coding gene Chr10:16706595-16721218 (-)
A/J MGP_AJ_G0017021
 protein coding gene Chr10:16068724-16083462 (-)
AKR/J MGP_AKRJ_G0016985
 protein coding gene Chr10:16332098-16346841 (-)
BALB/cJ MGP_BALBcJ_G0016979
 protein coding gene Chr10:16131649-16146387 (-)
C3H/HeJ MGP_C3HHeJ_G0016804
 protein coding gene Chr10:16659048-16673787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017441
 protein coding gene Chr10:17118765-17134720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015146
 protein coding gene Chr10:15095752-15110463 (-)
CAST/EiJ MGP_CASTEiJ_G0016386
 protein coding gene Chr10:16493885-16510337 (-)
CBA/J MGP_CBAJ_G0016776
 protein coding gene Chr10:17892788-17907530 (-)
DBA/2J MGP_DBA2J_G0016884
 protein coding gene Chr10:15956502-15971243 (-)
FVB/NJ MGP_FVBNJ_G0016879
 protein coding gene Chr10:15716160-15730912 (-)
LP/J MGP_LPJ_G0016959
 protein coding gene Chr10:16525048-16539791 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016909
 protein coding gene Chr10:18174136-18188874 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017479
 protein coding gene Chr10:16317197-16331815 (-)
PWK/PhJ MGP_PWKPhJ_G0016171
 protein coding gene Chr10:15802516-15817318 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015954
 protein coding gene Chr10:16432569-16488063 (-)
WSB/EiJ MGP_WSBEiJ_G0016448
 protein coding gene Chr10:16418514-16434653 (-)



Homology
more
  • Human Ortholog
    TNFAIP3, TNF alpha induced protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFAIP3, TNF alpha induced protein 3
  • Synonyms
    A20, AIFBL1, AISBL, OTUD7C, TNFA1P2
  • Links
    NCBI Gene ID: 7128
    neXtProt AC: NX_P21580
    UniProt: P21580

  • Chr Location
    6q23.3; chr6:137866349-137883314 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human TNFAIP3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    107 phenotypes from 9 alleles in 10 genetic backgrounds
    8 phenotypes from multigenic genotypes
    2 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display runting, severe multi-organ inflammation, hypersensitivity to lipopolysaccharide and TNF, and premature death. Older mice homozygous for point mutations that disrupt deubiquitinating activity develop splenomegaly and show an increased number of myeloid cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    24
  • cDNA Data
    99
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21929 NCBI Gene Model | MGI Sequence Detail 14501 C57BL/6J ±  kb
    transcript NM_001428865 RefSeq | MGI Sequence Detail 4856 C57BL/6  
    polypeptide Q60769 UniProt | EBI | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 100
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 10
      Gene Ontology 31
      Phenotypes 91
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:351023 Torres-Huerta A, et al., Retinoid orphan receptor gamma t (rorgammat) promotes inflammatory eosinophilia but is dispensable for innate immune-mediated colitis. PLoS One. 2024;19(3):e0300892
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory