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Habp2 Gene Detail
Summary
  • Symbol
    Habp2
  • Name
    hyaluronic acid binding protein 2
  • Synonyms
    FSAP, MGC:28705
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196378
    NCBI Gene: 226243
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56275569-56309254 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 51.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196378
 protein coding gene Chr19:56275541-56309254 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025261
 protein coding gene Chr19:56621418-56659805 (+)
A/J MGP_AJ_G0025237
 protein coding gene Chr19:53827324-53862595 (+)
AKR/J MGP_AKRJ_G0025206
 protein coding gene Chr19:55521549-55561796 (+)
BALB/cJ MGP_BALBcJ_G0025232
 protein coding gene Chr19:53912647-53950546 (+)
C3H/HeJ MGP_C3HHeJ_G0024992
 protein coding gene Chr19:55761464-55800399 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025675
 protein coding gene Chr19:57985205-58023847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023087
 protein coding gene Chr19:52754405-52790031 (+)
CAST/EiJ MGP_CASTEiJ_G0024457
 protein coding gene Chr19:55776377-55811184 (+)
CBA/J MGP_CBAJ_G0024972
 protein coding gene Chr19:60852787-60898756 (+)
DBA/2J MGP_DBA2J_G0025104
 protein coding gene Chr19:53623106-53656755 (+)
FVB/NJ MGP_FVBNJ_G0025065
 protein coding gene Chr19:53327168-53360766 (+)
LP/J MGP_LPJ_G0025190
 protein coding gene Chr19:56486965-56522059 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025098
 protein coding gene Chr19:60170793-60206656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025733
 protein coding gene Chr19:55744214-55777804 (+)
PWK/PhJ MGP_PWKPhJ_G0024205
 protein coding gene Chr19:53569147-53604591 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024008
 protein coding gene Chr19:54412691-54450472 (+)
WSB/EiJ MGP_WSBEiJ_G0024527
 protein coding gene Chr19:55866963-55903665 (+)



Homology
more
  • Human Ortholog
    HABP2, hyaluronan binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HABP2, hyaluronan binding protein 2
  • Synonyms
    FSAP, HABP, HGFAL, NMTC5, PHBP
  • Links
    NCBI Gene ID: 3026
    neXtProt AC: NX_Q14520
    UniProt: Q14520

  • Chr Location
    10q25.3; chr10:113550831-113589602 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HABP2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased lethality but increased liver fibrosis, inflammation and injury following bile duct ligation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    13
  • cDNA Data
    50
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025075 Ensembl Gene Model | MGI Sequence Detail 33686 C57BL/6J ±  kb
    transcript ENSMUST00000078284 Ensembl | MGI Sequence Detail 2314 Not Applicable  
    polypeptide ENSMUSP00000077402 Ensembl | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 50
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147471
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 14
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:44782 Hashimoto K, et al., Cloning of the cDNA for a mouse homologue of human PHBP: a novel hyaluronan-binding protein. Biol Pharm Bull. 1997 Nov;20(11):1127-30
    • Latest
      J:354189 Miao L, et al., beta1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation. Cardiovasc Res. 2024 Sep 21;120(11):1279-1294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory