Slc25a39 MGI Mouse Gene Detail - MGI:1196386 - solute carrier family 25, member 39

Symbol

Slc25a39
Name

solute carrier family 25, member 39
Synonyms

3010027G13Rik, D11Ertd333e

Feature Type

protein coding gene
IDs

MGI:1196386
NCBI Gene: 68066
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:102293811-102298772 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.29 cM, cytoband D
Mapping Data

4 experiments

SNPs within 2kb

194 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196386	protein coding gene	Chr11:102293795-102299501 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019234	protein coding gene	Chr11:105373182-105378143 (-)
A/J	MGP_AJ_G0019202	protein coding gene	Chr11:100931028-100935985 (-)
AKR/J	MGP_AKRJ_G0019171	protein coding gene	Chr11:104048752-104053713 (-)
BALB/cJ	MGP_BALBcJ_G0019176	protein coding gene	Chr11:101412874-101417835 (-)
C3H/HeJ	MGP_C3HHeJ_G0018985	protein coding gene	Chr11:104254417-104259378 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019625	protein coding gene	Chr11:108666803-108671764 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017251	protein coding gene	Chr11:98357535-98362551 (-)
CAST/EiJ	MGP_CASTEiJ_G0018539	protein coding gene	Chr11:105247432-105252394 (-)
CBA/J	MGP_CBAJ_G0018954	protein coding gene	Chr11:113151746-113156707 (-)
DBA/2J	MGP_DBA2J_G0019066	protein coding gene	Chr11:100445652-100450613 (-)
FVB/NJ	MGP_FVBNJ_G0019056	protein coding gene	Chr11:99977840-99982801 (-)
LP/J	MGP_LPJ_G0019135	protein coding gene	Chr11:105896877-105901838 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019087	protein coding gene	Chr11:112646634-112651595 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019663	protein coding gene	Chr11:104417902-104422863 (-)
PWK/PhJ	MGP_PWKPhJ_G0018302	protein coding gene	Chr11:101514005-101518967 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018094	protein coding gene	Chr11:104174543-104179477 (-)
WSB/EiJ	MGP_WSBEiJ_G0018588	protein coding gene	Chr11:104413615-104418565 (-)

Human Ortholog

SLC25A39, solute carrier family 25 member 39

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A39, solute carrier family 25 member 39
Synonyms

CGI-69, CGI69
Links

HGNC:24279

NCBI Gene ID: 51629

neXtProt AC: NX_Q9BZJ4

UniProt: Q9BZJ4
Chr Location

17q21.31; chr17:44319625-44324870 (-) GRCh38

MGI Vertebrate Homology

Slc25a39 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC25A39
Gene Tree

Slc25a39

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

4
Gene trapped

15
Targeted

3
Genomic Mutations

1 involving Slc25a39
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

923
Tissues

48
cDNA Data

18
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a39

ZFIN slc25a39

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All Sequences

97
RefSeq

12
UniProt

11
CCDS

CCDS25498.1

Ensembl

ENSMUSG00000018677 (Evidence)
NCBI Gene

68066

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018677	Ensembl Gene Model \| MGI Sequence Detail	4962	C57BL/6J	± kb
transcript	ENSMUST00000018821	Ensembl \| MGI Sequence Detail	1685	Not Applicable
polypeptide	ENSMUSP00000018821	Ensembl \| MGI Sequence Detail	359	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000032515 probable mitochondrial glutathione transporter SLC25A39

(term hierarchy)
InterPro Domains

IPR023395 Mitochondrial carrier domain superfamily

IPR045315 Mitochondrial carrier protein Mtm1-like

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 4

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MGI:1915316

Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 17
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc25a39:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111072	Chr11:102298748-102298777 (-)	9 bp
Tssr111071	Chr11:102298725-102298739 (-)	40 bp
Tssr111070	Chr11:102298683-102298721 (-)	70 bp
Tssr111069	Chr11:102298281-102298354 (-)	454 bp
Tssr111068	Chr11:102298263-102298274 (-)	503 bp
Tssr111067	Chr11:102297609-102297654 (-)	1,140 bp
Tssr111066	Chr11:102297592-102297608 (-)	1,172 bp
Tssr111065	Chr11:102297568-102297578 (-)	1,199 bp
Tssr111064	Chr11:102297435-102297448 (-)	1,330 bp
Tssr111063	Chr11:102294108-102294122 (-)	4,657 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24