Ctdspl2 MGI Mouse Gene Detail - MGI:1196405 - CTD small phosphatase like 2

Symbol

Ctdspl2
Name

CTD small phosphatase like 2
Synonyms

D2Ertd485e, SCP4

Feature Type

protein coding gene
IDs

MGI:1196405
NCBI Gene: 329506
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:121786482-121844123 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.46 cM
Mapping Data

2 experiments

SNPs within 2kb

1067 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196405	protein coding gene	Chr2:121785879-121845807 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026401	protein coding gene	Chr2:124923278-124986495 (+)
A/J	MGP_AJ_G0026363	protein coding gene	Chr2:119808198-119877863 (+)
AKR/J	MGP_AKRJ_G0026340	protein coding gene	Chr2:123181013-123242182 (+)
BALB/cJ	MGP_BALBcJ_G0026375	protein coding gene	Chr2:120048136-120106352 (+)
C3H/HeJ	MGP_C3HHeJ_G0026121	protein coding gene	Chr2:123648901-123721838 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026823	protein coding gene	Chr2:128986240-129047969 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024200	protein coding gene	Chr2:114804258-114859716 (+)
CAST/EiJ	MGP_CASTEiJ_G0025582	protein coding gene	Chr2:123987584-124054213 (+)
CBA/J	MGP_CBAJ_G0026099	protein coding gene	Chr2:133517094-133583125 (+)
DBA/2J	MGP_DBA2J_G0026236	protein coding gene	Chr2:119213372-119270867 (+)
FVB/NJ	MGP_FVBNJ_G0026198	protein coding gene	Chr2:118015103-118073956 (+)
LP/J	MGP_LPJ_G0026338	protein coding gene	Chr2:125171452-125234947 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026218	protein coding gene	Chr2:137736625-137814181 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026877	protein coding gene	Chr2:123293311-123352683 (+)
PWK/PhJ	MGP_PWKPhJ_G0025318	protein coding gene	Chr2:118830608-118888885 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025118	protein coding gene	Chr2:122446010-122501733 (+)
WSB/EiJ	MGP_WSBEiJ_G0025654	protein coding gene	Chr2:124145172-124208252 (+)

Human Ortholog

CTDSPL2, CTD small phosphatase like 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTDSPL2, CTD small phosphatase like 2
Synonyms

HSPC058, HSPC129, SCP4
Links

HGNC:26936

NCBI Gene ID: 51496

neXtProt AC: NX_Q05D32

UniProt: Q05D32
Chr Location

15q15.3-q21.1; chr15:44427622-44529038 (+) GRCh38

MGI Vertebrate Homology

Ctdspl2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CTDSPL2
Gene Tree

Ctdspl2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

86
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

77
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Ctdspl2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

87 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

28
cDNA Data

23
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctdspl2

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All Sequences

73
RefSeq

11
UniProt

1
CCDS

CCDS16652.1, CCDS71130.1

Ensembl

ENSMUSG00000033411 (Evidence)
NCBI Gene

329506

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033411	Ensembl Gene Model \| MGI Sequence Detail	57642	C57BL/6J	± kb
transcript	ENSMUST00000036647	Ensembl \| MGI Sequence Detail	5053	Not Applicable
polypeptide	ENSMUSP00000047543	Ensembl \| MGI Sequence Detail	465	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006002 CTD small phosphatase-like protein 2

(term hierarchy)
EC

3.1.3.-
InterPro Domains

IPR011948 Dullard phosphatase domain, eukaryotic

IPR004274 FCP1 homology domain

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR050365 Mitochondrial import inner membrane translocase subunit TIM50

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 7

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 19
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ctdspl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19791	Chr2:121786445-121786463 (+)	-28 bp
Tssr19792	Chr2:121786616-121786646 (+)	149 bp
Tssr19793	Chr2:121786918-121786961 (+)	458 bp
Tssr19794	Chr2:121787132-121787145 (+)	657 bp
Tssr625	Chr2:121816158-121816163 (+)	29,679 bp
Tssr19795	Chr2:121818459-121818463 (+)	31,979 bp
Tssr19796	Chr2:121831139-121831144 (+)	44,660 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24