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Tnpo3 Gene Detail
Summary
  • Symbol
    Tnpo3
  • Name
    transportin 3
  • Synonyms
    5730544L10Rik, C430013M08Rik, D6Ertd313e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196412
    NCBI Gene: 320938
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29540826-29609886 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.36 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196412
 protein coding gene Chr6:29540826-29609918 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030528
 protein coding gene Chr6:27345421-27417131 (-)
A/J MGP_AJ_G0030501
 protein coding gene Chr6:26182724-26252103 (-)
AKR/J MGP_AKRJ_G0030428
 protein coding gene Chr6:27045557-27116800 (-)
BALB/cJ MGP_BALBcJ_G0030511
 protein coding gene Chr6:26339933-26412907 (-)
C3H/HeJ MGP_C3HHeJ_G0030224
 protein coding gene Chr6:27046073-27118944 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030965
 protein coding gene Chr6:28126232-28200036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028176
 protein coding gene Chr6:24391860-24462584 (-)
CAST/EiJ MGP_CASTEiJ_G0029626
 protein coding gene Chr6:26849816-26918470 (-)
CBA/J MGP_CBAJ_G0030202
 protein coding gene Chr6:29186332-29263797 (-)
DBA/2J MGP_DBA2J_G0030346
 protein coding gene Chr6:26130356-26200538 (-)
FVB/NJ MGP_FVBNJ_G0030300
 protein coding gene Chr6:25884272-25954260 (-)
LP/J MGP_LPJ_G0030433
 protein coding gene Chr6:27474718-27548786 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030336
 protein coding gene Chr6:31687550-31761079 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030995
 protein coding gene Chr6:26921113-26995516 (-)
PWK/PhJ MGP_PWKPhJ_G0029340
 protein coding gene Chr6:25663352-25734017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029176
 protein coding gene Chr6:26642704-26712138 (-)
WSB/EiJ MGP_WSBEiJ_G0029702
 protein coding gene Chr6:26892866-26963879 (-)



Homology
more
  • Human Ortholog
    TNPO3, transportin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNPO3, transportin 3
  • Synonyms
    IPO12, LGMD1F, LGMDD2, MTR10A, TRN-SR, TRNSR, TRN-SR2
  • Links
    NCBI Gene ID: 23534
    neXtProt AC: NX_Q9Y5L0
    UniProt: Q9Y5L0

  • Chr Location
    7q32.1; chr7:128954180-129056193 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TNPO3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000012535 Ensembl Gene Model | MGI Sequence Detail 69061 C57BL/6J ±  kb
    transcript ENSMUST00000115251 Ensembl | MGI Sequence Detail 3989 Not Applicable  
    polypeptide ENSMUSP00000110906 Ensembl | MGI Sequence Detail 929 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1913907, MGI:2141765, MGI:2445081
    References
    more
    • Summaries
      All 39
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:337059 Iwanami N, et al., Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR alpha chain of iNKT cells. Nat Commun. 2023 Jun 20;14(1):3645
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory