Onecut1 MGI Mouse Gene Detail - MGI:1196423 - one cut domain, family member 1

Symbol

Onecut1
Name

one cut domain, family member 1
Synonyms

D9Ertd423e, Hfh12, Hnf6, HNF6, Oc1, OC-1

Feature Type

protein coding gene
IDs

MGI:1196423
NCBI Gene: 15379
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:74769203-74796930 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 41.93 cM
Mapping Data

6 experiments

SNPs within 2kb

682 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196423	protein coding gene	Chr9:74769203-74799063 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035031	protein coding gene	Chr9:75126391-75156186 (+)
A/J	MGP_AJ_G0035012	protein coding gene	Chr9:72509202-72539132 (+)
AKR/J	MGP_AKRJ_G0034941	protein coding gene	Chr9:74251168-74280919 (+)
BALB/cJ	MGP_BALBcJ_G0035004	protein coding gene	Chr9:72194281-72223931 (+)
C3H/HeJ	MGP_C3HHeJ_G0034713	protein coding gene	Chr9:74717046-74746762 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035523	protein coding gene	Chr9:77125955-77157712 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032434	protein coding gene	Chr9:71884157-71913829 (+)
CAST/EiJ	MGP_CASTEiJ_G0034035	protein coding gene	Chr9:75043178-75074764 (+)
CBA/J	MGP_CBAJ_G0034686	protein coding gene	Chr9:79781263-79810912 (+)
DBA/2J	MGP_DBA2J_G0034845	protein coding gene	Chr9:72185513-72215213 (+)
FVB/NJ	MGP_FVBNJ_G0034787	protein coding gene	Chr9:71486771-71516369 (+)
LP/J	MGP_LPJ_G0034926	protein coding gene	Chr9:75390117-75419853 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034828	protein coding gene	Chr9:80889024-80919299 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035545	protein coding gene	Chr9:74409318-74441253 (+)
PWK/PhJ	MGP_PWKPhJ_G0033739	protein coding gene	Chr9:72460266-72490385 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033572	protein coding gene	Chr9:74629229-74658810 (+)
WSB/EiJ	MGP_WSBEiJ_G0034147	protein coding gene	Chr9:74315687-74345765 (+)

Human Ortholog

ONECUT1, one cut homeobox 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ONECUT1, one cut homeobox 1
Synonyms

HNF-6, HNF6, HNF6A
Links

HGNC:8138

NCBI Gene ID: 3175

neXtProt AC: NX_Q9UBC0

UniProt: Q9UBC0
Chr Location

15q21.3; chr15:52755053-52791078 (-) GRCh38

MGI Vertebrate Homology

Onecut1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ONECUT1
Gene Tree

Onecut1

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Phenotype Summary

52 phenotypes from 2 alleles in 5 genetic backgrounds
5 phenotypes from multigenic genotypes
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Targeted

5
Genomic Mutations

1 involving Onecut1
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in partial postnatal lethality, billiary tract, pancreas, and islet of Langerhans abnormalities, growth retardation, and glucose and insulin metabolism defects. Conditional KO in the retina results in progressive retinal degeneration.

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All GO Annotations

39
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1211
Tissues

218
cDNA Data

11
Literature Summary

118

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase onecut1, onecut1.2

ZFIN onecut1

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS23339.1

Ensembl

ENSMUSG00000043013 (Evidence)
NCBI Gene

15379

			Length	Strain/Species	Flank
genomic	15379	NCBI Gene Model \| MGI Sequence Detail	27728	C57BL/6J	± kb
transcript	NM_008262	RefSeq \| MGI Sequence Detail	1824	ZRU/MplStud
polypeptide	O08755	UniProt \| EBI \| MGI Sequence Detail	465	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011639 hepatocyte nuclear factor 6

(term hierarchy)
PDB

1S7E
InterPro Domains

IPR003350 CUT domain

IPR051649 CUT Homeobox Domain-Containing Protein

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR010982 Lambda repressor-like, DNA-binding domain superfamily

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All nucleic 33

cDNA 12

Primer pair 16

Other 5

Microarray probesets 6

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MGI:1261757, MGI:1329018

Summaries

All 180

Developmental Gene Expression 118

Gene Ontology 15

Phenotypes 47
Earliest

J:46149 Samadani U, et al., The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol Cell Biol. 1996 Nov;16(11):6273-84
Latest

J:357897 Renaux E, et al., Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Front Cell Neurosci. 2024;18:1466056

TSS for Onecut1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86108	Chr9:74769139-74769146 (+)	-60 bp
Tssr86109	Chr9:74769157-74769166 (+)	-41 bp
Tssr86110	Chr9:74769170-74769197 (+)	-19 bp
Tssr2940	Chr9:74769218-74769219 (+)	16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24