Ccn4 MGI Mouse Gene Detail - MGI:1197008 - cellular communication network factor 4

Symbol

Ccn4
Name

cellular communication network factor 4
Synonyms

CCN4, Elm1, Wisp1

Feature Type

protein coding gene
IDs

MGI:1197008
NCBI Gene: 22402
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:66763337-66795050 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 29.30 cM
Mapping Data

3 experiments

SNPs within 2kb

1125 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1197008	protein coding gene	Chr15:66763169-66795050 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021909	protein coding gene	Chr15:66414761-66446627 (+)
A/J	MGP_AJ_G0021868	protein coding gene	Chr15:63903765-63935828 (+)
AKR/J	MGP_AKRJ_G0021850	protein coding gene	Chr15:65668732-65700653 (+)
BALB/cJ	MGP_BALBcJ_G0021875	protein coding gene	Chr15:64087057-64118929 (+)
C3H/HeJ	MGP_C3HHeJ_G0021648	protein coding gene	Chr15:65791108-65822980 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022314	protein coding gene	Chr15:68989335-69021192 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019851	protein coding gene	Chr15:60683735-60715589 (+)
CAST/EiJ	MGP_CASTEiJ_G0021167	protein coding gene	Chr15:66451922-66484243 (+)
CBA/J	MGP_CBAJ_G0021614	protein coding gene	Chr15:71277512-71309384 (+)
DBA/2J	MGP_DBA2J_G0021739	protein coding gene	Chr15:63685918-63717798 (+)
FVB/NJ	MGP_FVBNJ_G0021721	protein coding gene	Chr15:62723153-62754974 (+)
LP/J	MGP_LPJ_G0021811	protein coding gene	Chr15:66309067-66340946 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021744	protein coding gene	Chr15:76377108-76409038 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022336	protein coding gene	Chr15:66043906-66075841 (+)
PWK/PhJ	MGP_PWKPhJ_G0020908	protein coding gene	Chr15:63784530-63816982 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020749	protein coding gene	Chr15:65916192-65949741 (+)
WSB/EiJ	MGP_WSBEiJ_G0021219	protein coding gene	Chr15:66014414-66046256 (+)

Human Ortholog

CCN4, cellular communication network factor 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCN4, cellular communication network factor 4
Synonyms

WISP1, WISP1c, WISP1i, WISP1-OT1, WISP1tc, WISP1-UT1
Links

HGNC:12769

NCBI Gene ID: 8840

neXtProt AC: NX_O95388

UniProt: O95388
Chr Location

8q24.22; chr8:133191039-133231690 (+) GRCh38

MGI Vertebrate Homology

Ccn4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCN4
Protein SuperFamily

IGFBP_rP_CNN
Gene Tree

Ccn4

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

3
Endonuclease-mediated

5
Radiation induced

2
Targeted

3
Genomic Mutations

5 involving Ccn4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a targeted mutation exhibit impaired motor coordination during inverted screen testing.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1269
Tissues

123
cDNA Data

14
Literature Summary

20

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WISP1

ZFIN ccn4b

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All Sequences

49
RefSeq

4
UniProt

4
CCDS

CCDS27510.1

Ensembl

ENSMUSG00000005124 (Evidence)
NCBI Gene

22402

			Length	Strain/Species	Flank
genomic	22402	NCBI Gene Model \| MGI Sequence Detail	31714	C57BL/6J	± kb
transcript	NM_018865	RefSeq \| MGI Sequence Detail	4929	ZRU/MplStud
polypeptide	O54775	UniProt \| EBI \| MGI Sequence Detail	367	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017426 CCN family member 4

(term hierarchy)
InterPro Domains

IPR043973 CCN, TSP1 domain

IPR050941 Cellular Communication Network Factor

IPR006207 Cystine knot, C-terminal

IPR006208 Glycoprotein hormone subunit beta

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR012395 IGFBP-related, CNN

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR001007 VWFC domain
GlyGen

O54775 4 sites

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All nucleic 27

cDNA 14

Primer pair 10

Other 3

Microarray probesets 4

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MGI:2146202, MGI:6209571

Summaries

All 94

Developmental Gene Expression 20

Diseases 1

Gene Ontology 12

Phenotypes 36
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:351705 Li Z, et al., WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts' Activation and Collagen Processing. Cells. 2024 Jun 6;13(11)

TSS for Ccn4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131487	Chr15:66763212-66763224 (+)	-119 bp
Tssr131488	Chr15:66763227-66763238 (+)	-104 bp
Tssr131489	Chr15:66763263-66763279 (+)	-66 bp
Tssr131490	Chr15:66763306-66763317 (+)	-25 bp
Tssr131491	Chr15:66763326-66763344 (+)	-2 bp
Tssr131492	Chr15:66763388-66763395 (+)	55 bp
Tssr131493	Chr15:66781104-66781121 (+)	17,776 bp
Tssr131494	Chr15:66781138-66781149 (+)	17,807 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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