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Aatk Gene Detail
Summary
  • Symbol
    Aatk
  • Name
    apoptosis-associated tyrosine kinase
  • Synonyms
    AATYK1, mKIAA0641
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197518
    NCBI Gene: 11302
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119898139-119937993 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    964 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197518
 protein coding gene Chr11:119898137-119938009 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019488
 protein coding gene Chr11:124437631-124480430 (-)
A/J MGP_AJ_G0019456
 protein coding gene Chr11:118909713-118949322 (-)
AKR/J MGP_AKRJ_G0019426
 protein coding gene Chr11:122489141-122528931 (-)
BALB/cJ MGP_BALBcJ_G0019431
 protein coding gene Chr11:119265318-119305101 (-)
C3H/HeJ MGP_C3HHeJ_G0019237
 protein coding gene Chr11:122809865-122849650 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019880
 protein coding gene Chr11:128204637-128248786 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017505
 protein coding gene Chr11:115912629-115952323 (-)
CAST/EiJ MGP_CASTEiJ_G0018791
 protein coding gene Chr11:124286409-124326711 (-)
CBA/J MGP_CBAJ_G0019208
 protein coding gene Chr11:133220571-133263289 (-)
DBA/2J MGP_DBA2J_G0019320
 protein coding gene Chr11:118275525-118315958 (-)
FVB/NJ MGP_FVBNJ_G0019312
 protein coding gene Chr11:117964046-118005575 (-)
LP/J MGP_LPJ_G0019392
 protein coding gene Chr11:124746507-124789872 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019345
 protein coding gene Chr11:132088645-132131722 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019919
 protein coding gene Chr11:123170385-123211807 (-)
PWK/PhJ MGP_PWKPhJ_G0018557
 protein coding gene Chr11:119701952-119742876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018349
 protein coding gene Chr11:122934576-122977456 (-)
WSB/EiJ MGP_WSBEiJ_G0018843
 protein coding gene Chr11:123165561-123206372 (-)



Homology
more
  • Human Ortholog
    AATK, apoptosis associated tyrosine kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AATK, apoptosis associated tyrosine kinase
  • Synonyms
    AATYK, AATYK1, LMR1, LMTK1, p35BP, PPP1R77
  • Links
    NCBI Gene ID: 9625
    neXtProt AC: NX_Q6ZMQ8
    UniProt: Q6ZMQ8

  • Chr Location
    17q25.3; chr17:81110487-81166221 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased brain size, longer axons and fewer neurites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    12
  • cDNA Data
    56
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025375 Ensembl Gene Model | MGI Sequence Detail 39855 C57BL/6J ±  kb
    transcript ENSMUST00000064307 Ensembl | MGI Sequence Detail 5336 Not Applicable  
    polypeptide ENSMUSP00000067181 Ensembl | MGI Sequence Detail 1374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000003535 serine/threonine-protein kinase LMTK1
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR042817 Serine/threonine-protein kinase LMTK1, catalytic domain
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
    • GlyGen
      Q80YE4 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 56
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:45453 Gaozza E, et al., AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene. 1997 Dec 18;15(25):3127-35
    • Latest
      J:339746 Jin R, et al., Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis. Exp Mol Med. 2023 Jan;55(1):69-80
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory