Bcl2l11 MGI Mouse Gene Detail - MGI:1197519

Symbol

Bcl2l11
Name

BCL2 like 11
Synonyms

1500006F24Rik, Bim, Bod

Feature Type

protein coding gene
IDs

MGI:1197519
NCBI Gene: 12125
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:127967958-128004467 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.23 cM, cytoband F3-G1
Mapping Data

4 experiments

SNPs within 2kb

892 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1197519	protein coding gene	Chr2:127967958-128004467 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026471	protein coding gene	Chr2:131443575-131481578 (+)
A/J	MGP_AJ_G0026435	protein coding gene	Chr2:126125375-126161995 (+)
AKR/J	MGP_AKRJ_G0026410	protein coding gene	Chr2:129717212-129753593 (+)
BALB/cJ	MGP_BALBcJ_G0026447	protein coding gene	Chr2:126383463-126420301 (+)
C3H/HeJ	MGP_C3HHeJ_G0026190	protein coding gene	Chr2:130227779-130264286 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026892	protein coding gene	Chr2:135559133-135595560 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024269	protein coding gene	Chr2:120954174-120990717 (+)
CAST/EiJ	MGP_CASTEiJ_G0025651	protein coding gene	Chr2:130440755-130479581 (+)
CBA/J	MGP_CBAJ_G0026170	protein coding gene	Chr2:140581975-140618474 (+)
DBA/2J	MGP_DBA2J_G0026304	protein coding gene	Chr2:125521657-125558824 (+)
FVB/NJ	MGP_FVBNJ_G0026268	protein coding gene	Chr2:124166689-124204149 (+)
LP/J	MGP_LPJ_G0026409	protein coding gene	Chr2:131682223-131718612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026288	protein coding gene	Chr2:144566237-144603870 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026947	protein coding gene	Chr2:129735888-129772453 (+)
PWK/PhJ	MGP_PWKPhJ_G0025387	protein coding gene	Chr2:125084521-125121851 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025189	protein coding gene	Chr2:128837400-128873819 (+)
WSB/EiJ	MGP_WSBEiJ_G0025725	protein coding gene	Chr2:130646548-130683000 (+)

Human Ortholog

BCL2L11, BCL2 like 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCL2L11, BCL2 like 11
Synonyms

BAM, BIM, BOD
Links

HGNC:994

NCBI Gene ID: 10018

neXtProt AC: NX_O43521

UniProt: O43521
Chr Location

2q13; chr2:111119378-111168445 (+) GRCh38

MGI Vertebrate Homology

Bcl2l11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BCL2L11
Protein SuperFamily

Bcl-2-like_p11
Gene Tree

Bcl2l11

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Phenotype Summary

85 phenotypes from 14 alleles in 19 genetic backgrounds
102 phenotypes from multigenic genotypes
2 images
282 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

9
Radiation induced

1
Targeted

21
Genomic Mutations

2 involving Bcl2l11
Incidental Mutations

APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Consistent with this gene's role in hematopoietic homeostasis, homozygous null mutants accumulate lymphoid and myeloid cells and succumb to autoimmune kidney disease.

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All GO Annotations

99
GO References

34

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

21
cDNA Data

22
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcl2l11

ZFIN bcl2l11

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All Sequences

91
RefSeq

30
UniProt

5
CCDS

CCDS16712.1, CCDS16713.1, CCDS16714.1, CCDS71141.1

Ensembl

ENSMUSG00000027381 (Evidence)
NCBI Gene

12125

			Length	Strain/Species	Flank
genomic	12125	NCBI Gene Model \| MGI Sequence Detail	36510	C57BL/6J	± kb
transcript	NM_207680	RefSeq \| MGI Sequence Detail	5040	C57BL/6
polypeptide	O54918	UniProt \| EBI \| MGI Sequence Detail	196	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000002187 Bcl-2-like protein 11

(term hierarchy)
PDB

1PQ1
InterPro Domains

IPR014771 Apoptosis, Bim N-terminal

IPR017288 Bcl-2-like protein 11

IPR015040 Bcl-x interacting, BH3 domain

IPR052133 Immune Signaling and Apoptosis Regulator

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All nucleic 29

Genomic 1

cDNA 25

Primer pair 3

Microarray probesets 8

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MGI:1923589

Summaries

All 447

Developmental Gene Expression 36

Gene Ontology 34

Phenotypes 282
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346017 Ou Q, et al., Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation. Cell Metab. 2024 Jan 2;36(1):78-89.e5

TSS for Bcl2l11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20042	Chr2:127967950-127967976 (+)	5 bp
Tssr20043	Chr2:127969478-127969492 (+)	1,527 bp
Tssr20044	Chr2:127969507-127969563 (+)	1,577 bp
Tssr20045	Chr2:127970031-127970044 (+)	2,080 bp
Tssr20046	Chr2:127970045-127970072 (+)	2,101 bp
Tssr20047	Chr2:127970637-127970655 (+)	2,688 bp
Tssr20048	Chr2:127974538-127974542 (+)	6,582 bp
Tssr20049	Chr2:128000611-128000617 (+)	32,656 bp
Tssr639	Chr2:128001184-128001189 (+)	33,229 bp
Tssr20050	Chr2:128001205-128001215 (+)	33,252 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24