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Irx2 Gene Detail
Summary
  • Symbol
    Irx2
  • Name
    Iroquois homeobox 2
  • Synonyms
    IRX6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197526
    NCBI Gene: 16372
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:72776939-72782317 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 39.23 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197526
 protein coding gene Chr13:72771463-72782317 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020740
 protein coding gene Chr13:73021975-73028926 (+)
A/J MGP_AJ_G0020696
 protein coding gene Chr13:70444716-70450097 (+)
AKR/J MGP_AKRJ_G0020671
 protein coding gene Chr13:72659173-72665877 (+)
BALB/cJ MGP_BALBcJ_G0020693
 protein coding gene Chr13:70940170-70947268 (+)
C3H/HeJ MGP_C3HHeJ_G0020488
 protein coding gene Chr13:72363552-72368908 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021130
 protein coding gene Chr13:75508005-75515342 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018698
 protein coding gene Chr13:67246013-67251362 (+)
CAST/EiJ MGP_CASTEiJ_G0020005
 protein coding gene Chr13:71405070-71421903 (+)
CBA/J MGP_CBAJ_G0020446
 protein coding gene Chr13:78329421-78334777 (+)
DBA/2J MGP_DBA2J_G0020572
 protein coding gene Chr13:70269845-70275200 (+)
FVB/NJ MGP_FVBNJ_G0020552
 protein coding gene Chr13:69293555-69299297 (+)
LP/J MGP_LPJ_G0020644
 protein coding gene Chr13:73277928-73284436 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020580
 protein coding gene Chr13:76778138-76784324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021169
 protein coding gene Chr13:71955171-71960843 (+)
PWK/PhJ MGP_PWKPhJ_G0019759
 protein coding gene Chr13:68986628-69003543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019582
 protein coding gene Chr13:68432072-68437423 (+)
WSB/EiJ MGP_WSBEiJ_G0020062
 protein coding gene Chr13:72496915-72504018 (+)



Homology
more
  • Human Ortholog
    IRX2, iroquois homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRX2, iroquois homeobox 2
  • Synonyms
    IRXA2
  • Links
    NCBI Gene ID: 153572
    neXtProt AC: NX_Q9BZI1
    UniProt: Q9BZI1

  • Chr Location
    5p15.33; chr5:2735635-2751677 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Mice homozygous for disruptions in this gene are phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1383
  • Tissues
    375
  • cDNA Data
    124
  • Literature Summary
    62
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001504 Ensembl Gene Model | MGI Sequence Detail 5379 C57BL/6J ±  kb
transcript ENSMUST00000074372 Ensembl | MGI Sequence Detail 2625 Not Applicable  
polypeptide ENSMUSP00000073976 Ensembl | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 137
    cDNA 125
    Primer pair 7
    Other 5

    Microarray probesets 3
References
more
  • Summaries
    All 101
    Developmental Gene Expression 62
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:357424 Ma ZG, et al., IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice. Nat Commun. 2023 Aug 16;14(1):4967
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory