Top3a MGI Mouse Gene Detail - MGI:1197527 - topoisomerase (DNA) III alpha

Symbol

Top3a
Name

topoisomerase (DNA) III alpha
Synonyms

Top IIIa

Feature Type

protein coding gene
IDs

MGI:1197527
NCBI Gene: 21975
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:60630884-60668191 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.81 cM
Mapping Data

3 experiments

SNPs within 2kb

1115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1197527	protein coding gene	Chr11:60629014-60668191 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018424	protein coding gene	Chr11:60654591-60696261 (-)
A/J	MGP_AJ_G0018393	protein coding gene	Chr11:58423153-58462306 (-)
AKR/J	MGP_AKRJ_G0018363	protein coding gene	Chr11:60276578-60313690 (-)
BALB/cJ	MGP_BALBcJ_G0018364	protein coding gene	Chr11:58720019-58757807 (-)
C3H/HeJ	MGP_C3HHeJ_G0018177	protein coding gene	Chr11:60211888-60252957 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018816	protein coding gene	Chr11:62575537-62618018 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016462	protein coding gene	Chr11:55565805-55600747 (-)
CAST/EiJ	MGP_CASTEiJ_G0017734	protein coding gene	Chr11:60309601-60351337 (-)
CBA/J	MGP_CBAJ_G0018151	protein coding gene	Chr11:65301267-65342128 (-)
DBA/2J	MGP_DBA2J_G0018260	protein coding gene	Chr11:58009607-58047115 (-)
FVB/NJ	MGP_FVBNJ_G0018251	protein coding gene	Chr11:57671568-57710259 (-)
LP/J	MGP_LPJ_G0018333	protein coding gene	Chr11:61235293-61273461 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018275	protein coding gene	Chr11:66354278-66405279 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018857	protein coding gene	Chr11:60368121-60408510 (-)
PWK/PhJ	MGP_PWKPhJ_G0017507	protein coding gene	Chr11:58587589-58627170 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017297	protein coding gene	Chr11:60183994-60222594 (-)
WSB/EiJ	MGP_WSBEiJ_G0017786	protein coding gene	Chr11:59988928-60028020 (-)

Human Ortholog

TOP3A, DNA topoisomerase III alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOP3A, DNA topoisomerase III alpha
Synonyms

MGRISCE2, PEOB5, TOP3, ZGRF7
Links

HGNC:11992

NCBI Gene ID: 7156

neXtProt AC: NX_Q13472

UniProt: Q13472
Chr Location

17p11.2; chr17:18271428-18315007 (-) GRCh38

MGI Vertebrate Homology

Top3a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TOP3A
Gene Tree

Top3a

Diseases

1 with human TOP3A associations

				Human Disease	Mouse Models
				autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 IDs autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 DOID:0111524 OMIM:618098

Click on a disease name to see all genes associated with that disease.

References

2 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Targeted

6
Genomic Mutations

3 involving Top3a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available

Mice homozygous for a null allele die shortly after implantation and the induction of decidual reaction.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

65
cDNA Data

17
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase top3a

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All Sequences

54
RefSeq

4
UniProt

9
CCDS

CCDS24797.1

Ensembl

ENSMUSG00000002814 (Evidence)
NCBI Gene

21975

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002814	Ensembl Gene Model \| MGI Sequence Detail	37308	C57BL/6J	± kb
transcript	ENSMUST00000002891	Ensembl \| MGI Sequence Detail	3741	Not Applicable
polypeptide	ENSMUSP00000002891	Ensembl \| MGI Sequence Detail	1003	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000016546 DNA topoisomerase 3-alpha

(term hierarchy)
EC

5.6.2.1
InterPro Domains

IPR034144 DNA topoisomerase 3-like, TOPRIM domain

IPR000380 DNA topoisomerase, type IA

IPR023406 DNA topoisomerase, type IA, active site

IPR013497 DNA topoisomerase, type IA, central

IPR013824 DNA topoisomerase, type IA, central region, subdomain 1

IPR013825 DNA topoisomerase, type IA, central region, subdomain 2

IPR013826 DNA topoisomerase, type IA, central region, subdomain 3

IPR023405 DNA topoisomerase, type IA, core domain

IPR003602 DNA topoisomerase, type IA, DNA-binding domain

IPR003601 DNA topoisomerase, type IA, domain 2

IPR013498 DNA topoisomerase, type IA, zn finger

IPR006171 TOPRIM domain

IPR010666 Zinc finger, GRF-type

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All nucleic 23

Genomic 4

cDNA 17

Primer pair 2

Microarray probesets 3

Summaries

All 59

Developmental Gene Expression 6

Diseases 2

Gene Ontology 8

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Top3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108306	Chr11:60668261-60668286 (-)	-83 bp
Tssr108305	Chr11:60668067-60668110 (-)	102 bp
Tssr108304	Chr11:60668052-60668065 (-)	132 bp
Tssr108303	Chr11:60668040-60668051 (-)	145 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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