Nlk MGI Mouse Gene Detail - MGI:1201387

Symbol

Nlk
Name

nemo like kinase

Feature Type

protein coding gene
IDs

MGI:1201387
NCBI Gene: 18099
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:78457994-78588199 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

2 experiments

SNPs within 2kb

2678 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201387	protein coding gene	Chr11:78457994-78588848 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018788	protein coding gene	Chr11:79588795-79732641 (-)
A/J	MGP_AJ_G0018755	protein coding gene	Chr11:76543694-76676785 (-)
AKR/J	MGP_AKRJ_G0018725	protein coding gene	Chr11:78845553-78975655 (-)
BALB/cJ	MGP_BALBcJ_G0018728	protein coding gene	Chr11:76942669-77076339 (-)
C3H/HeJ	MGP_C3HHeJ_G0018542	protein coding gene	Chr11:78898048-79030513 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019180	protein coding gene	Chr11:82061696-82201476 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016815	protein coding gene	Chr11:73508760-73640319 (-)
CAST/EiJ	MGP_CASTEiJ_G0018097	protein coding gene	Chr11:79348127-79480777 (-)
CBA/J	MGP_CBAJ_G0018513	protein coding gene	Chr11:85676418-85806328 (-)
DBA/2J	MGP_DBA2J_G0018621	protein coding gene	Chr11:76112906-76247814 (-)
FVB/NJ	MGP_FVBNJ_G0018610	protein coding gene	Chr11:75701268-75839312 (-)
LP/J	MGP_LPJ_G0018691	protein coding gene	Chr11:80105870-80256131 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018637	protein coding gene	Chr11:86028330-86159863 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019220	protein coding gene	Chr11:79097761-79234764 (-)
PWK/PhJ	MGP_PWKPhJ_G0017867	protein coding gene	Chr11:76910080-77042209 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017658	protein coding gene	Chr11:78707163-78842727 (-)
WSB/EiJ	MGP_WSBEiJ_G0018149	protein coding gene	Chr11:78928881-79065135 (-)

Human Ortholog

NLK, nemo like kinase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NLK, nemo like kinase
Links

HGNC:29858

NCBI Gene ID: 51701

neXtProt AC: NX_Q9UBE8

UniProt: Q9UBE8
Chr Location

17q11.2; chr17:28041737-28206074 (+) GRCh38

MGI Vertebrate Homology

Nlk stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NLK
Gene Tree

Nlk

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Phenotype Summary

26 phenotypes from 5 alleles in 7 genetic backgrounds
2 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

77
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

65
Targeted

9
Transgenic

1
Genomic Mutations

3 involving Nlk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation die either during late gestation or around 4-6 weeks, depending on background. Long survivors exhibit growth retardation, neurological abnormalities, and aberrant differentiation of bone marrow stromal cells.

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All GO Annotations

38
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

57
cDNA Data

60
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nlk, nlk.2

ZFIN nlk1, nlk2

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All Sequences

54
RefSeq

9
UniProt

3
CCDS

CCDS25113.2

Ensembl

ENSMUSG00000017376 (Evidence)
NCBI Gene

18099

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017376	Ensembl Gene Model \| MGI Sequence Detail	130206	C57BL/6J	± kb
transcript	ENSMUST00000142739	Ensembl \| MGI Sequence Detail	4444	Not Applicable
polypeptide	ENSMUSP00000119345	Ensembl \| MGI Sequence Detail	527	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011259 serine/threonine-protein kinase NLK

(term hierarchy)
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

O54949 1 site, 1 O-linked glycan (1 site)

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All nucleic 64

cDNA 61

Primer pair 2

Other 1

Microarray probesets 6

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MGI:2144078

Summaries

All 85

Developmental Gene Expression 10

Gene Ontology 14

Phenotypes 33
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nlk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109420	Chr11:78588411-78588431 (-)	-222 bp
Tssr109419	Chr11:78588196-78588301 (-)	-50 bp
Tssr109418	Chr11:78588109-78588116 (-)	86 bp
Tssr109417	Chr11:78587322-78587367 (-)	854 bp
Tssr109416	Chr11:78587030-78587050 (-)	1,159 bp
Tssr109415	Chr11:78585043-78585047 (-)	3,154 bp
Tssr109414	Chr11:78580835-78580839 (-)	7,362 bp
Tssr109413	Chr11:78547891-78547895 (-)	40,306 bp
Tssr109412	Chr11:78543508-78543511 (-)	44,689 bp
Tssr3589	Chr11:78539975-78539977 (-)	48,223 bp
Tssr109411	Chr11:78498995-78498999 (-)	89,202 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24