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Rdh5 Gene Detail
Summary
  • Symbol
    Rdh5
  • Name
    retinol dehydrogenase 5
  • Synonyms
    cRDH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201412
    NCBI Gene: 19682
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128749457-128755906 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201412
 protein coding gene Chr10:128749457-128758757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017889
 protein coding gene Chr10:132714601-132723878 (-)
A/J MGP_AJ_G0017864
 protein coding gene Chr10:127370476-127379772 (-)
AKR/J MGP_AKRJ_G0017827
 protein coding gene Chr10:131086178-131097063 (-)
BALB/cJ MGP_BALBcJ_G0017828
 protein coding gene Chr10:127730344-127739642 (-)
C3H/HeJ MGP_C3HHeJ_G0017651
 protein coding gene Chr10:131262706-131272052 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018283
 protein coding gene Chr10:137186766-137196059 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015961
 protein coding gene Chr10:121277625-121287193 (-)
CAST/EiJ MGP_CASTEiJ_G0017212
 protein coding gene Chr10:131990089-132001623 (-)
CBA/J MGP_CBAJ_G0017621
 protein coding gene Chr10:142784294-142793644 (-)
DBA/2J MGP_DBA2J_G0017727
 protein coding gene Chr10:126427607-126437028 (-)
FVB/NJ MGP_FVBNJ_G0017722
 protein coding gene Chr10:125348753-125358312 (-)
LP/J MGP_LPJ_G0017801
 protein coding gene Chr10:133291683-133301587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017750
 protein coding gene Chr10:145339608-145348946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018323
 protein coding gene Chr10:131196006-131205284 (-)
PWK/PhJ MGP_PWKPhJ_G0016997
 protein coding gene Chr10:126696739-126706115 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016786
 protein coding gene Chr10:130312251-130321578 (-)
WSB/EiJ MGP_WSBEiJ_G0017271
 protein coding gene Chr10:131428207-131437483 (-)



Homology
more
  • Human Ortholog
    RDH5, retinol dehydrogenase 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RDH5, retinol dehydrogenase 5
  • Synonyms
    9cRDH, HSD17B9, RDH1, SDR9C5
  • Links
    NCBI Gene ID: 5959
    neXtProt AC: NX_Q92781
    UniProt: Q92781

  • Chr Location
    12q13.2; chr12:55720367-55724705 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human RDH5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit an impaired dark adaptation and at high bleaching levels, a large increase in 11-cis-retinyl ester concentration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1009
  • Tissues
    202
  • cDNA Data
    20
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19682 NCBI Gene Model | MGI Sequence Detail 6450 C57BL/6J ±  kb
    transcript NM_001428784 RefSeq | MGI Sequence Detail 2405 C57BL/6  
    polypeptide O55240 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 21
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143706
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:44704 Driessen CA, et al., Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997 Dec 5;203(1):27-31
    • Latest
      J:289971 Xie Y, et al., A spectral-domain optical coherence tomographic analysis of Rdh5-/- mice retina. PLoS One. 2020;15(4):e0231220
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory