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Hs3st1 Gene Detail
Summary
  • Symbol
    Hs3st1
  • Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 1
  • Synonyms
    3-OST, D5Wsu110e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201606
    NCBI Gene: 15476
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:39771278-39802791 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 21.14 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    926 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201606
 protein coding gene Chr5:39771278-39912818 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029516
 protein coding gene Chr5:38083414-38229652 (-)
A/J MGP_AJ_G0029482
 protein coding gene Chr5:36808057-36948076 (-)
AKR/J MGP_AKRJ_G0029432
 protein coding gene Chr5:38155326-38299072 (-)
BALB/cJ MGP_BALBcJ_G0029493
 protein coding gene Chr5:37260229-37400316 (-)
C3H/HeJ MGP_C3HHeJ_G0029216
 protein coding gene Chr5:38154576-38298297 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029947
 protein coding gene Chr5:40067808-40215785 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027185
 protein coding gene Chr5:34418637-34554568 (-)
CAST/EiJ MGP_CASTEiJ_G0028624
 protein coding gene Chr5:37333597-37485434 (-)
CBA/J MGP_CBAJ_G0029183
 protein coding gene Chr5:40992312-41148054 (-)
DBA/2J MGP_DBA2J_G0029330
 protein coding gene Chr5:36903526-37044532 (-)
FVB/NJ MGP_FVBNJ_G0029289
 protein coding gene Chr5:36391223-36528805 (-)
LP/J MGP_LPJ_G0029416
 protein coding gene Chr5:38529403-38678604 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029319
 protein coding gene Chr5:41730289-41879877 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029980
 protein coding gene Chr5:37676202-37818872 (-)
PWK/PhJ MGP_PWKPhJ_G0028348
 protein coding gene Chr5:36085852-36224637 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028182
 protein coding gene Chr5:37140174-37297010 (-)
WSB/EiJ MGP_WSBEiJ_G0028705
 protein coding gene Chr5:37762285-37908425 (-)



Homology
more
  • Human Ortholog
    HS3ST1, heparan sulfate-glucosamine 3-sulfotransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HS3ST1, heparan sulfate-glucosamine 3-sulfotransferase 1
  • Synonyms
    3OST, 3OST1
  • Links
    NCBI Gene ID: 9957
    neXtProt AC: NX_O14792
    UniProt: O14792

  • Chr Location
    4p15.33; chr4:11393150-11434327 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Hs3st1
  • Incidental Mutations
    Mutagenetix
  • Find Mice (IMSR)
    18 strains or lines available
Homozygous mutation of this gene results in embryonic growth retardation and death between postnatal days 2-3 when bred on a C57BL/6J background. Mice homozygous for this mutation on a 129 background are normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    144
  • cDNA Data
    47
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15476 NCBI Gene Model | MGI Sequence Detail 31514 C57BL/6J ±  kb
transcript NM_001421581 RefSeq | MGI Sequence Detail 1865 ZRU/MplStud  
polypeptide O35310 UniProt | EBI | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 47
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-34175, MGI:106481
References
more
  • Summaries
    All 68
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 10
    Phenotypes 25
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory