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Psmd4 Gene Detail
Summary
  • Symbol
    Psmd4
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
  • Synonyms
    Af1, angiocidin, Mcb1, multiubiquitin-chain-binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201670
    NCBI Gene: 19185
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94939999-94949880 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201670
 protein coding gene Chr3:94939999-94949925 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027565
 protein coding gene Chr3:95713070-95725526 (-)
A/J MGP_AJ_G0027524
 protein coding gene Chr3:92769631-92780506 (-)
AKR/J MGP_AKRJ_G0027491
 protein coding gene Chr3:94906453-94916251 (-)
BALB/cJ MGP_BALBcJ_G0027536
 protein coding gene Chr3:92539280-92549126 (-)
C3H/HeJ MGP_C3HHeJ_G0027269
 protein coding gene Chr3:95181532-95191242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027984
 protein coding gene Chr3:99281516-99291374 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025324
 protein coding gene Chr3:89130710-89140627 (-)
CAST/EiJ MGP_CASTEiJ_G0026719
 protein coding gene Chr3:94472363-94482702 (-)
CBA/J MGP_CBAJ_G0027246
 protein coding gene Chr3:102865822-102883205 (-)
DBA/2J MGP_DBA2J_G0027385
 protein coding gene Chr3:92063045-92073055 (-)
FVB/NJ MGP_FVBNJ_G0027356
 protein coding gene Chr3:90132343-90142217 (-)
LP/J MGP_LPJ_G0027494
 protein coding gene Chr3:97007550-97018780 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027383
 protein coding gene Chr3:109008519-109021118 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028038
 protein coding gene Chr3:94557112-94568473 (-)
PWK/PhJ MGP_PWKPhJ_G0026447
 protein coding gene Chr3:91934078-91945870 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026268
 protein coding gene Chr3:92855392-92866833 (-)
WSB/EiJ MGP_WSBEiJ_G0026801
 protein coding gene Chr3:94947715-94957522 (-)



Homology
more
  • Human Ortholog
    PSMD4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4
  • Synonyms
    AF, AF-1, ASF, MCB1, pUB-R5, Rpn10, S5A
  • Links
    NCBI Gene ID: 5710
    neXtProt AC: NX_P55036
    UniProt: P55036

  • Chr Location
    1q21.3; chr1:151254709-151267479 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality and abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    22
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19185 NCBI Gene Model | MGI Sequence Detail 9882 C57BL/6J ±  kb
transcript NM_001282017 RefSeq | MGI Sequence Detail 1286 ZRU/MplStud  
polypeptide O35226 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36380, MGI:107803
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:343081 Zhang R, et al., Lipid-anchored proteasomes control membrane protein homeostasis. Sci Adv. 2023 Dec;9(48):eadj4605
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory