Tesk1 MGI Mouse Gene Detail - MGI:1201675 - testis specific protein kinase 1

Symbol

Tesk1
Name

testis specific protein kinase 1

Feature Type

protein coding gene
IDs

MGI:1201675
NCBI Gene: 21754
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr4:43442277-43448075 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.04 cM, cytoband A5-C1
Mapping Data

2 experiments

SNPs within 2kb

266 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201675	protein coding gene	Chr4:43441939-43448075 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028205	protein coding gene	Chr4:41553085-41559210 (+)
A/J	MGP_AJ_G0028161	protein coding gene	Chr4:40080406-40086496 (+)
AKR/J	MGP_AKRJ_G0028113	protein coding gene	Chr4:40992096-40998244 (+)
BALB/cJ	MGP_BALBcJ_G0028181	protein coding gene	Chr4:40170112-40176202 (+)
C3H/HeJ	MGP_C3HHeJ_G0027903	protein coding gene	Chr4:41617199-41623289 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028622	protein coding gene	Chr4:43114106-43120231 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025934	protein coding gene	Chr4:37531461-37537805 (+)
CAST/EiJ	MGP_CASTEiJ_G0027343	protein coding gene	Chr4:41121654-41127783 (+)
CBA/J	MGP_CBAJ_G0027869	protein coding gene	Chr4:44418800-44424918 (+)
DBA/2J	MGP_DBA2J_G0028018	protein coding gene	Chr4:39992374-39998492 (+)
FVB/NJ	MGP_FVBNJ_G0027985	protein coding gene	Chr4:39210574-39216692 (+)
LP/J	MGP_LPJ_G0028117	protein coding gene	Chr4:41609952-41616077 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028009	protein coding gene	Chr4:47683388-47689536 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028658	protein coding gene	Chr4:41185189-41191314 (+)
PWK/PhJ	MGP_PWKPhJ_G0027069	protein coding gene	Chr4:40034890-40041012 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026895	protein coding gene	Chr4:40751302-40757415 (+)
WSB/EiJ	MGP_WSBEiJ_G0027423	protein coding gene	Chr4:41089841-41095969 (+)

Human Ortholog

TESK1, testis associated actin remodelling kinase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TESK1, testis associated actin remodelling kinase 1
Links

HGNC:11731

NCBI Gene ID: 7016

neXtProt AC: NX_Q15569

UniProt: Q15569
Chr Location

9p13.3; chr9:35605262-35610041 (+) GRCh38

MGI Vertebrate Homology

Tesk1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TESK1
Gene Tree

Tesk1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically and radiation induced

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Tesk1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

49
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

2
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tesk1

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS18094.1

Ensembl

ENSMUSG00000028458 (Evidence)
NCBI Gene

21754

			Length	Strain/Species	Flank
genomic	21754	NCBI Gene Model \| MGI Sequence Detail	5799	C57BL/6J	± kb
transcript	NM_011571	RefSeq \| MGI Sequence Detail	3620	C57BL/6
polypeptide	O70146	UniProt \| EBI \| MGI Sequence Detail	627	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016241 dual specificity testis-specific protein kinase 1

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR050940 Actin-regulating Serine/Threonine Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site
GlyGen

O70146 1 site, 1 N-linked glycan (1 site)

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All nucleic 15

Genomic 4

cDNA 9

Primer pair 2

Microarray probesets 3

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MGI:2140247

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 6
Earliest

J:46073 Toshima J, et al., Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene. Gene. 1998 Jan 12;206(2):237-45
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tesk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36949	Chr4:43442236-43442315 (+)	-1 bp
Tssr36950	Chr4:43442320-43442339 (+)	53 bp
Tssr36951	Chr4:43442360-43442369 (+)	88 bp
Tssr36952	Chr4:43442402-43442411 (+)	130 bp
Tssr36953	Chr4:43442468-43442483 (+)	199 bp
Tssr36954	Chr4:43442484-43442501 (+)	216 bp
Tssr36955	Chr4:43442514-43442527 (+)	244 bp
Tssr36956	Chr4:43442560-43442567 (+)	287 bp
Tssr36957	Chr4:43443079-43443090 (+)	808 bp
Tssr36958	Chr4:43443102-43443130 (+)	839 bp
Tssr36959	Chr4:43443135-43443156 (+)	869 bp
Tssr36960	Chr4:43443157-43443169 (+)	886 bp
Tssr36961	Chr4:43446005-43446028 (+)	3,740 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24