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Ctbp2 Gene Detail
Summary
  • Symbol
    Ctbp2
  • Name
    C-terminal binding protein 2
  • Synonyms
    D7Ertd45e, Gtrgeo6, Ribeye
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201686
    NCBI Gene: 13017
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132589292-132726083 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 76.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3685 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201686
 protein coding gene Chr7:132588727-132726083 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033119
 protein coding gene Chr7:137699884-137849705 (-)
A/J MGP_AJ_G0033101
 protein coding gene Chr7:133907530-134048557 (-)
AKR/J MGP_AKRJ_G0033033
 protein coding gene Chr7:137477213-137621338 (-)
BALB/cJ MGP_BALBcJ_G0033102
 protein coding gene Chr7:133591692-133732996 (-)
C3H/HeJ MGP_C3HHeJ_G0032816
 protein coding gene Chr7:137313761-137462918 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033613
 protein coding gene Chr7:142944849-143094379 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030584
 protein coding gene Chr7:135189310-135326948 (-)
CAST/EiJ MGP_CASTEiJ_G0032146
 protein coding gene Chr7:129228116-129372562 (-)
CBA/J MGP_CBAJ_G0032789
 protein coding gene Chr7:147776143-147925852 (-)
DBA/2J MGP_DBA2J_G0032941
 protein coding gene Chr7:131922204-132063758 (-)
FVB/NJ MGP_FVBNJ_G0032894
 protein coding gene Chr7:131760759-131898965 (-)
LP/J MGP_LPJ_G0033035
 protein coding gene Chr7:139219159-139365223 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032926
 protein coding gene Chr7:148691469-148844298 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033633
 protein coding gene Chr7:136474601-136625603 (-)
PWK/PhJ MGP_PWKPhJ_G0031852
 protein coding gene Chr7:124943130-125082311 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031698
 protein coding gene Chr7:123248178-123394682 (-)
WSB/EiJ MGP_WSBEiJ_G0032257
 protein coding gene Chr7:137372907-137513005 (-)



Homology
more
  • Human Ortholog
    CTBP2, C-terminal binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTBP2, C-terminal binding protein 2
  • Links
    NCBI Gene ID: 1488
    neXtProt AC: NX_P56545
    UniProt: P56545

  • Chr Location
    10q26.13; chr10:124984317-125162463 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene-trapped allele die by E10 exhibiting a small size, axial truncations, a thin neural epithelium, a dilated pericardium, delayed fore- and midbrain development, and defects in heart morphogenesis, placental development and extraembryonic vascularization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    83
  • cDNA Data
    27
  • Literature Summary
    61
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030970 Ensembl Gene Model | MGI Sequence Detail 136792 C57BL/6J ±  kb
    transcript ENSMUST00000169570 Ensembl | MGI Sequence Detail 3604 Not Applicable  
    polypeptide ENSMUSP00000130294 Ensembl | MGI Sequence Detail 988 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000005995 C-terminal-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR051638 C-terminal-binding dehydrogenase
      IPR043322 C-terminal binding protein
      IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
      IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      P56546 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 28
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098619, MGI:2141805, MGI:894664
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 61
      Gene Ontology 25
      Phenotypes 32
    • Earliest
      J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory