| Human Disease | Mouse Models | ||||
|---|---|---|---|---|---|
|
IDs
|
early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr143822 | Chr17:34138030-34138037 (+) | -418 bp |
| Tssr143823 | Chr17:34138444-34138451 (+) | -4 bp |
| Tssr143824 | Chr17:34138460-34138472 (+) | 14 bp |
| Tssr143825 | Chr17:34138537-34138553 (+) | 93 bp |
| Tssr143826 | Chr17:34138571-34138591 (+) | 129 bp |
| Tssr143827 | Chr17:34138593-34138602 (+) | 146 bp |
| Tssr143828 | Chr17:34138619-34138650 (+) | 183 bp |
| Tssr143829 | Chr17:34138653-34138664 (+) | 207 bp |
| Tssr143830 | Chr17:34138699-34138710 (+) | 253 bp |
| Tssr143831 | Chr17:34138801-34138807 (+) | 352 bp |
| Tssr143832 | Chr17:34138836-34138851 (+) | 392 bp |
| Tssr143833 | Chr17:34139216-34139311 (+) | 812 bp |
| Tssr143834 | Chr17:34139372-34139388 (+) | 928 bp |
| Tssr143835 | Chr17:34139464-34139488 (+) | 1,024 bp |
| Tssr143836 | Chr17:34139496-34139528 (+) | 1,060 bp |
| Tssr143837 | Chr17:34141778-34141826 (+) | 3,350 bp |
| Tssr143838 | Chr17:34144374-34144419 (+) | 5,945 bp |
| Tssr143839 | Chr17:34144443-34144465 (+) | 6,002 bp |
| Tssr143840 | Chr17:34144669-34144684 (+) | 6,225 bp |
| Tssr143841 | Chr17:34144706-34144738 (+) | 6,270 bp |
| Tssr143842 | Chr17:34144966-34145003 (+) | 6,533 bp |
| Tssr143843 | Chr17:34145139-34145165 (+) | 6,700 bp |
| Tssr143844 | Chr17:34145239-34145253 (+) | 6,794 bp |
| Tssr143845 | Chr17:34145286-34145300 (+) | 6,841 bp |
| Tssr143846 | Chr17:34145385-34145388 (+) | 6,935 bp |
| Tssr143847 | Chr17:34145391-34145403 (+) | 6,945 bp |
| Tssr143848 | Chr17:34145423-34145441 (+) | 6,980 bp |
| Tssr143849 | Chr17:34145593-34145611 (+) | 7,150 bp |
| Tssr143850 | Chr17:34145631-34145650 (+) | 7,189 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Pas2 | Chr17, 17.98 cM | Chr17:35422141-35424327 | J:78525 | Microarray gene expression analysis was used to identify candidate genes for tumor resistant and tumor susceptibility QTLs Par8,2,3,4 and and Pas1-4, respectively. Transcripts found within the flanking markers of each QTL were identified and matched to transcripts from Affymetrix probe sets. RNA from A/J, BALB/cJ, C57BL/6J, and SM/J were used for analysis. Pas1 is located between 48.2 cM and 75 cM on mouse Chromosome 6 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are hes related protein (**Note- this gene is not found in MGD), Ppih (cyclophilin H **Note-this gene is positioned on mouse Chromosome 4 in MGD), Ptpro, Mglap, Recql, and Bcat1 (ECA39). Other candidate genes identified via differential expression are Ccnd2 (cyclin D2) and high mobility group protein 2A,4 (**Note-this gene is not found in MGD). K-ras, a positional candidate gene, did not show significantly different expression between A/J and C57BL/6J. Pas2 is located between 17 cMand 23.2 cM on mouse Chromosome 17 and was identified in crosses involving A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Notch4, Hnrpk (**Note-this gene is positioned on mouse Chromosome 13 in MGD), and Enpp4. Other candidate genes identified via differential expression are Cdc5l, Tapbp (tapasin), H2-Ke2, Rbx1 (regulator of cullins 1 **Note- this gene is found on mouse Chromosome 15 in MGD), Psors1c2, H2-Ke6, and H2-M9. Positional candidate genes Tnf (Tnfa) and Lta (Tnfb) did not show significantly different expression between A/J and C57BL/6J. Pas3 is located between 2 cM and 25 cM on mouse Chromosome 19 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are golgi specific Gbf1 (brefeldin A resistance factor 1) and Sema4g. Other candidate genes identified via differential expression are Pdcd4, Adrb1, and Cdc25l. Pas4 is located between 42 cM and 72 cM on mouse Chromosome 9 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Nck1, Pthr1, and Topbp1. Candidate tumor suppressor genes for Pas4 are G protein alpha I 2 (**Note-this gene is not found in MGD), Cdk5 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), Smarcd3 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), and Nckipsd. Another candidate gene identified via differential expression is Stag1. Par1 is located between 37 cM and 59 cM on mouse Chromosome 11 and was identified in a cross between A/J and SM/J. Candidate oncogenic genes identified by microarray analysis are Alox12 (12-lipoxygenase), Zfp617 (zinc finger protein s11-6), Grn, and Rpl29 (**Note-this gene is positioned on mouse Chromosome 9 in MGD). A tumor suppressor candidate gene for Par1 is Spop. 02.05.2016 Curator Note: Because Par1 was originally mapped in J:32079 using an (A/J x M. spretus) x C57BL/6J interspecific backcross, which differs from the cross used here, we have equated this QTL with Par8 which was mapped using A/J and SM/J mice, see J:41849. Par2 is located between 32 cM and 57 cM on mouse Chromosome 18 and was identified in a cross between A/J and BALB/cJ. Candidate oncogenic genes identified by microarray analysis are Adrb2, Mbd2, Htr4, Hmgb1-rs12, and Iigp1. Dcc is an expected candidate gene of Par2 but its expression pattern (A/J=high expression) is not consistent with its effect on tumor resistance/susceptibility. Mc2r is another candidate gene identified via differential gene expression between A/J and SM/J. Par3 is located between 13 cM and 44 cM on mouse Chromosome 12 and was identified in a cross between A/J and SM/J. Only one candidate oncogenic gene was identified for Par3. This is placental growth factor, Pgf. Par4 is located between 10.6 cM and 42.5 cM on mouse Chromosome 4 and was identified in a cross between A/J and BALB/cJ. Candidate tumor suppressor genes identified via differential gene expression are Cdkn2a, Egfl5, Ambp (bikunin), Pole3, Tyrp1, Ifnab, and Igfbpl1.Candidate oncogenes are T complex protein 1 alpha (**Note-this gene is not found in MGD) and Stmn1. Another candidate gene identified via differential expression between A/J and SM/J is Ptprd. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/05/2024 MGI 6.24 |
|
|
|
||
Analysis Tools