Socs3 MGI Mouse Gene Detail - MGI:1201791 - suppressor of cytokine signaling 3

Symbol

Socs3
Name

suppressor of cytokine signaling 3
Synonyms

CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3

Feature Type

protein coding gene
IDs

MGI:1201791
NCBI Gene: 12702
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:117856905-117860192 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1201791	protein coding gene	Chr11:117856905-117860873 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019459	protein coding gene	Chr11:122266035-122270003 (-)
A/J	MGP_AJ_G0019427	protein coding gene	Chr11:116842490-116846524 (-)
AKR/J	MGP_AKRJ_G0019397	protein coding gene	Chr11:120396236-120400204 (-)
BALB/cJ	MGP_BALBcJ_G0019402	protein coding gene	Chr11:117211260-117215228 (-)
C3H/HeJ	MGP_C3HHeJ_G0019208	protein coding gene	Chr11:120691033-120695001 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019851	protein coding gene	Chr11:126002985-126006953 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017476	protein coding gene	Chr11:113853358-113857332 (-)
CAST/EiJ	MGP_CASTEiJ_G0018762	protein coding gene	Chr11:122103875-122110862 (-)
CBA/J	MGP_CBAJ_G0019179	protein coding gene	Chr11:130936866-130940834 (-)
DBA/2J	MGP_DBA2J_G0019291	protein coding gene	Chr11:116236796-116240764 (-)
FVB/NJ	MGP_FVBNJ_G0019283	protein coding gene	Chr11:115864570-115868540 (-)
LP/J	MGP_LPJ_G0019361	protein coding gene	Chr11:122587007-122590975 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019316	protein coding gene	Chr11:129906322-129910292 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019890	protein coding gene	Chr11:121048334-121052302 (-)
PWK/PhJ	MGP_PWKPhJ_G0018528	protein coding gene	Chr11:117598422-117605406 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018320	protein coding gene	Chr11:120775916-120779885 (-)
WSB/EiJ	MGP_WSBEiJ_G0018814	protein coding gene	Chr11:121010047-121014016 (-)

Human Ortholog

SOCS3, suppressor of cytokine signaling 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SOCS3, suppressor of cytokine signaling 3
Synonyms

ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
Links

HGNC:19391

NCBI Gene ID: 9021

neXtProt AC: NX_O14543

UniProt: O14543
Chr Location

17q25.3; chr17:78356778-78360925 (-) GRCh38

MGI Vertebrate Homology

Socs3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SOCS3
Gene Tree

Socs3

Diseases

1 with human SOCS3 associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

58 phenotypes from 7 alleles in 9 genetic backgrounds
163 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

3
Gene trapped

9
Targeted

8
Transgenic

1
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality.

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All GO Annotations

37
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

23
cDNA Data

54
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase socs3, socs3l

ZFIN socs3a, socs3b

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All Sequences

50
RefSeq

2
UniProt

2
CCDS

CCDS25697.1

Ensembl

ENSMUSG00000053113 (Evidence)
NCBI Gene

12702

			Length	Strain/Species	Flank
genomic	12702	NCBI Gene Model \| MGI Sequence Detail	3288	C57BL/6J	± kb
transcript	NM_007707	RefSeq \| MGI Sequence Detail	2742	C57BL/6
polypeptide	O35718	UniProt \| EBI \| MGI Sequence Detail	225	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015394 suppressor of cytokine signaling 3

(term hierarchy)
PDB

2BBU, 2HMH, 2JZ3, 4GL9
InterPro Domains

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR035863 SOCS3, SH2 domain

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

IPR028414 Suppressor of cytokine signalling 3, SOCS box domain

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All nucleic 58

cDNA 54

Primer pair 4

Microarray probesets 7

Summaries

All 322

Developmental Gene Expression 18

Gene Ontology 17

Phenotypes 163
Earliest

J:42258 Minamoto S, et al., Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem Biophys Res Commun. 1997 Aug 8;237(1):79-83
Latest

J:358124 Delpech C, et al., Axon guidance during mouse central nervous system regeneration is required for specific brain innervation. Dev Cell. 2024 Sep 26;

TSS for Socs3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112064	Chr11:117861169-117861180 (-)	-983 bp
Tssr112063	Chr11:117860731-117860764 (-)	-556 bp
Tssr112062	Chr11:117860210-117860242 (-)	-34 bp
Tssr112061	Chr11:117860110-117860123 (-)	75 bp
Tssr112060	Chr11:117860002-117860018 (-)	182 bp
Tssr112059	Chr11:117859537-117859571 (-)	638 bp
Tssr112058	Chr11:117859447-117859471 (-)	733 bp
Tssr112057	Chr11:117859009-117859050 (-)	1,162 bp
Tssr112056	Chr11:117858883-117858898 (-)	1,301 bp
Tssr112055	Chr11:117858785-117858793 (-)	1,403 bp
Tssr112054	Chr11:117858103-117858116 (-)	2,082 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24