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Pde1a Gene Detail
Summary
  • Symbol
    Pde1a
  • Name
    phosphodiesterase 1A, calmodulin-dependent
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201792
    NCBI Gene: 18573
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79664797-79959802 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 47.64 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8052 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201792
 protein coding gene Chr2:79664797-80026862 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025881
 protein coding gene Chr2:80398111-80705789 (-)
A/J MGP_AJ_G0025858
 protein coding gene Chr2:77295466-77589274 (-)
AKR/J MGP_AKRJ_G0025827
 protein coding gene Chr2:79310808-79622020 (-)
BALB/cJ MGP_BALBcJ_G0025854
 protein coding gene Chr2:77418505-77720034 (-)
C3H/HeJ MGP_C3HHeJ_G0025613
 protein coding gene Chr2:79541254-79852279 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026300
 protein coding gene Chr2:82770020-83087072 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023703
 protein coding gene Chr2:74544056-74824655 (-)
CAST/EiJ MGP_CASTEiJ_G0025075
 protein coding gene Chr2:79967542-80266600 (-)
CBA/J MGP_CBAJ_G0025594
 protein coding gene Chr2:85738996-86069357 (-)
DBA/2J MGP_DBA2J_G0025725
 protein coding gene Chr2:76839323-77129619 (-)
FVB/NJ MGP_FVBNJ_G0025687
 protein coding gene Chr2:76209265-76489087 (-)
LP/J MGP_LPJ_G0025813
 protein coding gene Chr2:80241883-80557745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025718
 protein coding gene Chr2:87602456-87945119 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026356
 protein coding gene Chr2:79490488-79787777 (-)
PWK/PhJ MGP_PWKPhJ_G0024818
 protein coding gene Chr2:76788267-77084386 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024624
 protein coding gene Chr2:79765376-80045869 (-)
WSB/EiJ MGP_WSBEiJ_G0025144
 protein coding gene Chr2:80108808-80406285 (-)



Homology
more
  • Human Ortholog
    PDE1A, phosphodiesterase 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE1A, phosphodiesterase 1A
  • Synonyms
    CAM-PDE 1A, CAM-PDE-1A, HCAM-1, HCAM1, HSPDE1A
  • Links
    NCBI Gene ID: 5136
    neXtProt AC: NX_P54750
    UniProt: P54750

  • Chr Location
    2q32.1; chr2:182139968-182716797 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit mild renal cystic disease with a urine concentrating defect, lower blood pressure and increased left ventricular ejection fraction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    973
  • Tissues
    167
  • cDNA Data
    37
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059173 Ensembl Gene Model | MGI Sequence Detail 295006 C57BL/6J ±  kb
    transcript ENSMUST00000102655 Ensembl | MGI Sequence Detail 4258 Not Applicable  
    polypeptide ENSMUSP00000099715 Ensembl | MGI Sequence Detail 545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012466 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.17
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminal
      IPR003607 HD/PDEase domain
    • GlyGen
      Q61481 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 38
      Primer pair 2
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139118, MGI:2139319
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:37553 Yan C, et al., Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9677-81
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory