Nmt2 MGI Mouse Gene Detail - MGI:1202298 - N-myristoyltransferase 2

Symbol

Nmt2
Name

N-myristoyltransferase 2
Synonyms

A930001K02Rik, hNMT-2

Feature Type

protein coding gene
IDs

MGI:1202298
NCBI Gene: 18108
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:3285249-3329914 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 1.84 cM
Mapping Data

2 experiments

SNPs within 2kb

789 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202298	protein coding gene	Chr2:3285249-3329914 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025303	protein coding gene	Chr2:240329-292894 (+)
A/J	MGP_AJ_G0025279	protein coding gene	Chr2:239406-284929 (+)
AKR/J	MGP_AKRJ_G0025248	protein coding gene	Chr2:229383-284742 (+)
BALB/cJ	MGP_BALBcJ_G0025275	protein coding gene	Chr2:217802-265665 (+)
C3H/HeJ	MGP_C3HHeJ_G0025035	protein coding gene	Chr2:250054-298115 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025718	protein coding gene	Chr2:235512-280896 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023132	protein coding gene	Chr2:191588-234824 (+)
CAST/EiJ	MGP_CASTEiJ_G0024499	protein coding gene	Chr2:235365-282685 (+)
CBA/J	MGP_CBAJ_G0025015	protein coding gene	Chr2:264605-310579 (+)
DBA/2J	MGP_DBA2J_G0025146	protein coding gene	Chr2:218656-263284 (+)
FVB/NJ	MGP_FVBNJ_G0025108	protein coding gene	Chr2:236353-280735 (+)
LP/J	MGP_LPJ_G0025233	protein coding gene	Chr2:253516-302074 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025141	protein coding gene	Chr2:245831-291950 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025776	protein coding gene	Chr2:244578-298507 (+)
PWK/PhJ	MGP_PWKPhJ_G0024248	protein coding gene	Chr2:219668-266486 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024050	protein coding gene	Chr2:248925-302530 (+)
WSB/EiJ	MGP_WSBEiJ_G0024569	protein coding gene	Chr2:247879-295180 (+)

Human Ortholog

NMT2, N-myristoyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NMT2, N-myristoyltransferase 2
Links

HGNC:7858

NCBI Gene ID: 9397

neXtProt AC: NX_O60551

UniProt: O60551
Chr Location

10p13; chr10:15102584-15168693 (-) GRCh38

MGI Vertebrate Homology

Nmt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NMT2
Protein SuperFamily

N-myristl_transf
Gene Tree

Nmt2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotypes from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

4
Targeted

6
Transgenic

1
Genomic Mutations

1 involving Nmt2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele knocked out in T cells exhibit reduced T cell, double positive T cell and single positive T cell numbers.

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

20
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nmt2

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All Sequences

54
RefSeq

12
UniProt

4
CCDS

CCDS15644.1, CCDS70971.1, CCDS70972.1

Ensembl

ENSMUSG00000026643 (Evidence)
NCBI Gene

18108

			Length	Strain/Species	Flank
genomic	18108	NCBI Gene Model \| MGI Sequence Detail	44666	C57BL/6J	± kb
transcript	NM_008708	RefSeq \| MGI Sequence Detail	4461	C57BL/6
polypeptide	O70311	UniProt \| EBI \| MGI Sequence Detail	529	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011294 glycylpeptide N-tetradecanoyltransferase 2

(term hierarchy)
EC

2.3.1.97
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR000903 Glycylpeptide N-tetradecanoyltransferase

IPR022678 Glycylpeptide N-tetradecanoyltransferase, conserved site

IPR022677 Glycylpeptide N-tetradecanoyltransferase, C-terminal

IPR022676 Glycylpeptide N-tetradecanoyltransferase, N-terminal
GlyGen

O70311 1 site, 1 N-linked glycan (1 site)

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All nucleic 19

cDNA 15

Primer pair 3

Other 1

Microarray probesets 6

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MGI:2139017, MGI:2139218, MGI:2445147

Summaries

All 71

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 42
Earliest

J:46538 Giang DK, et al., A second mammalian N-myristoyltransferase. J Biol Chem. 1998 Mar 20;273(12):6595-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nmt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15884	Chr2:3285206-3285219 (+)	-36 bp
Tssr15885	Chr2:3285239-3285257 (+)	-1 bp
Tssr15886	Chr2:3285269-3285327 (+)	49 bp
Tssr15887	Chr2:3328329-3328333 (+)	43,082 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24