Kcnu1 MGI Mouse Gene Detail - MGI:1202300 - potassium channel, subfamily U, member 1

Symbol

Kcnu1
Name

potassium channel, subfamily U, member 1
Synonyms

Kcnma3, Slo3

Feature Type

protein coding gene
IDs

MGI:1202300
NCBI Gene: 16532
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:26339651-26427967 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 14.17 cM, cytoband A3
Mapping Data

1 experiment

SNPs within 2kb

2233 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202300	protein coding gene	Chr8:26338656-26427971 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033491	protein coding gene	Chr8:23923114-24013285 (+)
A/J	MGP_AJ_G0033471	protein coding gene	Chr8:23053834-23137767 (+)
AKR/J	MGP_AKRJ_G0033396	protein coding gene	Chr8:23817639-23906770 (+)
BALB/cJ	MGP_BALBcJ_G0033467	protein coding gene	Chr8:23200432-23288047 (+)
C3H/HeJ	MGP_C3HHeJ_G0033181	protein coding gene	Chr8:24023709-24118549 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033983	protein coding gene	Chr8:24890953-24993891 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030933	protein coding gene	Chr8:20321718-20410703 (+)
CAST/EiJ	MGP_CASTEiJ_G0032507	protein coding gene	Chr8:23471598-23563727 (+)
CBA/J	MGP_CBAJ_G0033156	protein coding gene	Chr8:25867818-25963850 (+)
DBA/2J	MGP_DBA2J_G0033311	protein coding gene	Chr8:23023483-23107653 (+)
FVB/NJ	MGP_FVBNJ_G0033255	protein coding gene	Chr8:22829391-22918309 (+)
LP/J	MGP_LPJ_G0033400	protein coding gene	Chr8:23898121-23988864 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033298	protein coding gene	Chr8:25320452-25421651 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034002	protein coding gene	Chr8:23750876-23834851 (+)
PWK/PhJ	MGP_PWKPhJ_G0032218	protein coding gene	Chr8:22664463-22749423 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032052	protein coding gene	Chr8:23125256-23222076 (+)
WSB/EiJ	MGP_WSBEiJ_G0032623	protein coding gene	Chr8:23968984-24056666 (+)

Human Ortholog

KCNU1, potassium calcium-activated channel subfamily U member 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNU1, potassium calcium-activated channel subfamily U member 1
Synonyms

KCa5, KCa5.1, Kcnma3, KCNMC1, Slo3, SPGF79
Links

HGNC:18867

NCBI Gene ID: 157855

neXtProt AC: NX_A8MYU2

UniProt: A8MYU2
Chr Location

8p11.23; chr8:36784324-36936125 (+) GRCh38

MGI Vertebrate Homology

Kcnu1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KCNU1
Gene Tree

Kcnu1

Diseases

1 with human KCNU1 associations

				Human Disease	Mouse Models
				spermatogenic failure 79 IDs spermatogenic failure 79 DOID:0070578 OMIM:620196

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 3 alleles in 4 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Gene trapped

8
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous male mutants are infertile with impaired sperm capacitation.

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All GO Annotations

23
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

12
UniProt

2
CCDS

CCDS52530.1

Ensembl

ENSMUSG00000031576 (Evidence)
NCBI Gene

16532

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031576	Ensembl Gene Model \| MGI Sequence Detail	88317	C57BL/6J	± kb
transcript	ENSMUST00000098858	Ensembl \| MGI Sequence Detail	3536	Not Applicable
polypeptide	ENSMUSP00000096457	Ensembl \| MGI Sequence Detail	1121	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009271 potassium channel subfamily U member 1

(term hierarchy)
InterPro Domains

IPR048735 Ca2+-activated K+ channel Slowpoke-like, C-terminal domain

IPR003929 Calcium-activated potassium channel BK, alpha subunit

IPR047871 Calcium-activated potassium channel slowpoke-like

IPR005821 Ion transport domain

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All nucleic 6

cDNA 6

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 14
Earliest

J:45626 Schreiber M, et al., Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem. 1998 Feb 6;273(6):3509-16
Latest

J:298992 Balbach M, et al., Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm. Front Cell Dev Biol. 2020;8:572735

TSS for Kcnu1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76727	Chr8:26339638-26339645 (+)	-9 bp
Tssr76728	Chr8:26339646-26339661 (+)	3 bp
Tssr76729	Chr8:26339666-26339678 (+)	21 bp
Tssr76730	Chr8:26339688-26339693 (+)	40 bp
Tssr76731	Chr8:26339700-26339709 (+)	54 bp
Tssr76732	Chr8:26400243-26400247 (+)	60,594 bp
Tssr76733	Chr8:26401698-26401716 (+)	62,056 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24