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Hcrt Gene Detail
Summary
  • Symbol
    Hcrt
  • Name
    hypocretin
  • Synonyms
    orexin A, orexin B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202306
    NCBI Gene: 15171
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:100652519-100653757 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.60 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202306
 protein coding gene Chr11:100651895-100653757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019169
 protein coding gene Chr11:103533472-103535334 (-)
A/J MGP_AJ_G0019137
 protein coding gene Chr11:99212148-99214010 (-)
AKR/J MGP_AKRJ_G0019106
 protein coding gene Chr11:102292138-102294000 (-)
BALB/cJ MGP_BALBcJ_G0019111
 protein coding gene Chr11:99699750-99701612 (-)
C3H/HeJ MGP_C3HHeJ_G0018920
 protein coding gene Chr11:102457448-102459310 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019560
 protein coding gene Chr11:106742453-106744315 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017186
 protein coding gene Chr11:96628567-96630435 (-)
CAST/EiJ MGP_CASTEiJ_G0018474
 protein coding gene Chr11:103442150-103444012 (-)
CBA/J MGP_CBAJ_G0018889
 protein coding gene Chr11:111199849-111201711 (-)
DBA/2J MGP_DBA2J_G0019001
 protein coding gene Chr11:98748952-98750814 (-)
FVB/NJ MGP_FVBNJ_G0018991
 protein coding gene Chr11:98289090-98290952 (-)
LP/J MGP_LPJ_G0019070
 protein coding gene Chr11:104092292-104094154 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019022
 protein coding gene Chr11:110781793-110783655 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019598
 protein coding gene Chr11:102608482-102610344 (-)
PWK/PhJ MGP_PWKPhJ_G0018237
 protein coding gene Chr11:99788415-99790277 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018029
 protein coding gene Chr11:102352259-102354148 (-)
WSB/EiJ MGP_WSBEiJ_G0018523
 protein coding gene Chr11:102599966-102601828 (-)



Homology
more
  • Human Ortholog
    HCRT, hypocretin neuropeptide precursor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCRT, hypocretin neuropeptide precursor
  • Synonyms
    NRCLP1, OX, PPOX
  • Links
    NCBI Gene ID: 3060
    neXtProt AC: NX_O43612
    UniProt: O43612

  • Chr Location
    17q21.2; chr17:42184060-42185452 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hcrt mouse models; 2 with human HCRT associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit altered sleep patterns, frequent periods of behavioral arrest resembling human narcolepsy, and attenuated morphine dependence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    131
  • cDNA Data
    8
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15171 NCBI Gene Model | MGI Sequence Detail 1239 C57BL/6J ±  kb
    transcript NM_010410 RefSeq | MGI Sequence Detail 584 ZRU/MplStud  
    polypeptide O55241 UniProt | EBI | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 8
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 22
      Diseases 2
      Gene Ontology 8
      Phenotypes 104
    • Earliest
      J:45976 de Lecea L, et al., The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7
    • Latest
      J:351407 Braga A, et al., Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture. Nat Commun. 2024 Jul 16;15(1):5979
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory