Gpaa1 MGI Mouse Gene Detail - MGI:1202392 - GPI anchor attachment protein 1

Symbol

Gpaa1
Name

GPI anchor attachment protein 1
Synonyms

mGAA1

Feature Type

protein coding gene
IDs

MGI:1202392
NCBI Gene: 14731
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:76215494-76219099 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.72 cM, cytoband E
Mapping Data

3 experiments

SNPs within 2kb

132 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202392	protein coding gene	Chr15:76215431-76219107 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021984	protein coding gene	Chr15:76400449-76404125 (+)
A/J	MGP_AJ_G0021942	protein coding gene	Chr15:73619272-73622948 (+)
AKR/J	MGP_AKRJ_G0021925	protein coding gene	Chr15:75616770-75620446 (+)
BALB/cJ	MGP_BALBcJ_G0021951	protein coding gene	Chr15:73645374-73649050 (+)
C3H/HeJ	MGP_C3HHeJ_G0021723	protein coding gene	Chr15:75661422-75665098 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022391	protein coding gene	Chr15:79254751-79258427 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019920	protein coding gene	Chr15:70280729-70284406 (+)
CAST/EiJ	MGP_CASTEiJ_G0021242	protein coding gene	Chr15:76459432-76463108 (+)
CBA/J	MGP_CBAJ_G0021690	protein coding gene	Chr15:81753537-81757213 (+)
DBA/2J	MGP_DBA2J_G0021815	protein coding gene	Chr15:73155358-73159034 (+)
FVB/NJ	MGP_FVBNJ_G0021796	protein coding gene	Chr15:72204511-72208187 (+)
LP/J	MGP_LPJ_G0021886	protein coding gene	Chr15:76493004-76496680 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021820	protein coding gene	Chr15:87091745-87095421 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022411	protein coding gene	Chr15:75860959-75864635 (+)
PWK/PhJ	MGP_PWKPhJ_G0020983	protein coding gene	Chr15:73305123-73308799 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020823	protein coding gene	Chr15:75582232-75585904 (+)
WSB/EiJ	MGP_WSBEiJ_G0021294	protein coding gene	Chr15:75958247-75961923 (+)

Human Ortholog

GPAA1, glycosylphosphatidylinositol anchor attachment 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPAA1, glycosylphosphatidylinositol anchor attachment 1
Synonyms

GAA1, GPIBD15, hGAA1
Links

HGNC:4446

NCBI Gene ID: 8733

neXtProt AC: NX_O43292

UniProt: O43292
Chr Location

8q24.3; chr8:144082337-144093149 (+) GRCh38

MGI Vertebrate Homology

Gpaa1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPAA1
Protein SuperFamily

GAA1
Gene Tree

Gpaa1

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

3
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

2
Targeted

2
Genomic Mutations

5 involving Gpaa1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

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All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

173
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpaa1

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All Sequences

61
RefSeq

2
UniProt

5
CCDS

CCDS37120.1

Ensembl

ENSMUSG00000022561 (Evidence)
NCBI Gene

14731

			Length	Strain/Species	Flank
genomic	14731	NCBI Gene Model \| MGI Sequence Detail	3606	C57BL/6J	± kb
transcript	NM_010331	RefSeq \| MGI Sequence Detail	2036	C57BL/6
polypeptide	Q9WTK3	UniProt \| EBI \| MGI Sequence Detail	621	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008158 glycosylphosphatidylinositol anchor attachment 1 protein

(term hierarchy)
InterPro Domains

IPR007246 GPI transamidase component Gaa1
GlyGen

Q9WTK3 1 site

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All nucleic 175

Genomic 2

cDNA 173

Microarray probesets 5

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MGI:2146295

Summaries

All 60

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 32
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpaa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131774	Chr15:76215444-76215455 (+)	-44 bp
Tssr131775	Chr15:76215488-76215561 (+)	31 bp
Tssr131776	Chr15:76215710-76215740 (+)	231 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24