Pde7a MGI Mouse Gene Detail - MGI:1202402

Symbol

Pde7a
Name

phosphodiesterase 7A

Feature Type

protein coding gene
IDs

MGI:1202402
NCBI Gene: 18583
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr3:19277272-19365486 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 5.36 cM
Mapping Data

3 experiments

SNPs within 2kb

2483 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202402	protein coding gene	Chr3:19277272-19365486 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027092	protein coding gene	Chr3:16419671-16511012 (-)
A/J	MGP_AJ_G0027052	protein coding gene	Chr3:16353453-16442578 (-)
AKR/J	MGP_AKRJ_G0027021	protein coding gene	Chr3:16497022-16588183 (-)
BALB/cJ	MGP_BALBcJ_G0027064	protein coding gene	Chr3:16114239-16204791 (-)
C3H/HeJ	MGP_C3HHeJ_G0026805	protein coding gene	Chr3:16532570-16619640 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027509	protein coding gene	Chr3:17490691-17581962 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024870	protein coding gene	Chr3:14440217-14530350 (-)
CAST/EiJ	MGP_CASTEiJ_G0026260	protein coding gene	Chr3:16425672-16514783 (-)
CBA/J	MGP_CBAJ_G0026783	protein coding gene	Chr3:17850177-17947713 (-)
DBA/2J	MGP_DBA2J_G0026917	protein coding gene	Chr3:15959068-16048815 (-)
FVB/NJ	MGP_FVBNJ_G0026885	protein coding gene	Chr3:15618679-15706786 (-)
LP/J	MGP_LPJ_G0027029	protein coding gene	Chr3:17053138-17150094 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026906	protein coding gene	Chr3:19916726-20013967 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027568	protein coding gene	Chr3:16253116-16348624 (-)
PWK/PhJ	MGP_PWKPhJ_G0025993	protein coding gene	Chr3:15671973-15762174 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025801	protein coding gene	Chr3:16083798-16192036 (-)
WSB/EiJ	MGP_WSBEiJ_G0026334	protein coding gene	Chr3:16307262-16402589 (-)

Human Ortholog

PDE7A, phosphodiesterase 7A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDE7A, phosphodiesterase 7A
Synonyms

HCP1, PDE7
Links

HGNC:8791

NCBI Gene ID: 5150

neXtProt AC: NX_Q13946

UniProt: Q13946
Chr Location

8q13.1; chr8:65714334-65842322 (-) GRCh38

MGI Vertebrate Homology

Pde7a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDE7A
Gene Tree

Pde7a

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Endonuclease-mediated

2
Gene trapped

32
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Pde7a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available

Homozygous inactivation of this locus does not impair T cell function but affects the humoral immune response.

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All GO Annotations

11
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

108
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pde7a

ZFIN pde7a

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All Sequences

75
RefSeq

22
UniProt

6
CCDS

CCDS38398.1, CCDS50871.1

Ensembl

ENSMUSG00000069094 (Evidence)
NCBI Gene

18583

			Length	Strain/Species	Flank
genomic	18583	NCBI Gene Model \| MGI Sequence Detail	88215	C57BL/6J	± kb
transcript	NM_001122759	RefSeq \| MGI Sequence Detail	6343	C57BL/6
polypeptide	P70453	UniProt \| EBI \| MGI Sequence Detail	456	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012484 high affinity 3',5'-cyclic-AMP phosphodiesterase 7A

(term hierarchy)
EC

3.1.4.-, 3.1.4.53
InterPro Domains

IPR023088 3'5'-cyclic nucleotide phosphodiesterase

IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site

IPR003607 HD/PDEase domain

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All nucleic 20

cDNA 16

Primer pair 4

Microarray probesets 9

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MGI:2139861, MGI:2139950

Summaries

All 42

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 11
Earliest

J:49823 Bloom TJ, et al., Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14188-92
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Pde7a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32701	Chr3:19366356-19366377 (-)	-881 bp
Tssr32700	Chr3:19365553-19365567 (-)	-74 bp
Tssr32699	Chr3:19365513-19365542 (-)	-42 bp
Tssr32698	Chr3:19365497-19365508 (-)	-17 bp
Tssr32697	Chr3:19365433-19365478 (-)	30 bp
Tssr32696	Chr3:19365407-19365427 (-)	69 bp
Tssr32695	Chr3:19344200-19344205 (-)	21,283 bp
Tssr32694	Chr3:19319260-19319273 (-)	46,219 bp
Tssr32693	Chr3:19319171-19319187 (-)	46,307 bp
Tssr32692	Chr3:19319161-19319169 (-)	46,321 bp
Tssr32691	Chr3:19319123-19319138 (-)	46,355 bp
Tssr32690	Chr3:19319091-19319103 (-)	46,389 bp
Tssr32689	Chr3:19293041-19293062 (-)	72,434 bp
Tssr32688	Chr3:19292644-19292649 (-)	72,839 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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