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Rhag Gene Detail
Summary
  • Symbol
    Rhag
  • Name
    Rhesus blood group-associated A glycoprotein
  • Synonyms
    CD241, Rh50, Rh50A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202713
    NCBI Gene: 19743
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:41122017-41151645 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.54 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    748 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202713
 protein coding gene Chr17:41121990-41154985 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023761
 protein coding gene Chr17:41615301-41645984 (+)
A/J MGP_AJ_G0023719
 protein coding gene Chr17:40663049-40691772 (+)
AKR/J MGP_AKRJ_G0023690
 protein coding gene Chr17:40840669-40868619 (+)
BALB/cJ MGP_BALBcJ_G0023723
 protein coding gene Chr17:40592795-40629962 (+)
C3H/HeJ MGP_C3HHeJ_G0023487
 protein coding gene Chr17:41525617-41555669 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024165
 protein coding gene Chr17:43473518-43502315 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021616
 protein coding gene Chr17:37757846-37785767 (+)
CAST/EiJ MGP_CASTEiJ_G0022968
 protein coding gene Chr17:41534934-41566887 (+)
CBA/J MGP_CBAJ_G0023463
 protein coding gene Chr17:45007953-45043620 (+)
DBA/2J MGP_DBA2J_G0023589
 protein coding gene Chr17:39471836-39503766 (+)
FVB/NJ MGP_FVBNJ_G0023556
 protein coding gene Chr17:39115806-39150147 (+)
LP/J MGP_LPJ_G0023670
 protein coding gene Chr17:42253789-42285311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023585
 protein coding gene Chr17:44448748-44485894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024211
 protein coding gene Chr17:41164725-41197289 (+)
PWK/PhJ MGP_PWKPhJ_G0022713
 protein coding gene Chr17:38833300-38863220 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022528
 protein coding gene Chr17:38138498-38172212 (+)
WSB/EiJ MGP_WSBEiJ_G0023033
 protein coding gene Chr17:41720429-41753924 (+)



Homology
more
  • Human Ortholog
    RHAG, Rh associated glycoprotein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHAG, Rh associated glycoprotein
  • Synonyms
    CD241, OHS, OHST, RH2, Rh50, RH50A, Rh50GP, RHNR, SLC42A1
  • Links
    NCBI Gene ID: 6005
    neXtProt AC: NX_Q02094
    UniProt: Q02094

  • Chr Location
    6p12.3; chr6:49605175-49636839 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human RHAG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
 View 2 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased ammonium and methylammonium transport in red cell ghosts, reduced basal adhesion of red blood cells to endothelial cells, a slight increase in iron levels, and decreased transferrin levels in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    110
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023926 Ensembl Gene Model | MGI Sequence Detail 29629 C57BL/6J ±  kb
    transcript ENSMUST00000024721 Ensembl | MGI Sequence Detail 2339 Not Applicable  
    polypeptide ENSMUSP00000024721 Ensembl | MGI Sequence Detail 438 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 1
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:49131 Kitano T, et al., Conserved evolution of the Rh50 gene compared to its homologous Rh blood group gene. Biochem Biophys Res Commun. 1998 Aug 10;249(1):78-85
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory