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Tcf7l1 Gene Detail
Summary
  • Symbol
    Tcf7l1
  • Name
    transcription factor 7 like 1 (T cell specific, HMG box)
  • Synonyms
    Tcf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202876
    NCBI Gene: 21415
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72603354-72766028 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202876
 protein coding gene Chr6:72603354-72766237 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030883
 protein coding gene Chr6:73198349-73375802 (-)
A/J MGP_AJ_G0030853
 protein coding gene Chr6:70354756-70521318 (-)
AKR/J MGP_AKRJ_G0030782
 protein coding gene Chr6:72428943-72607878 (-)
BALB/cJ MGP_BALBcJ_G0030864
 protein coding gene Chr6:70382275-70548037 (-)
C3H/HeJ MGP_C3HHeJ_G0030848
 protein coding gene Chr6:111646005-111814120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031322
 protein coding gene Chr6:75110308-75279575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028511
 protein coding gene Chr6:69494165-69656461 (-)
CAST/EiJ MGP_CASTEiJ_G0029972
 protein coding gene Chr6:72297239-72471246 (-)
CBA/J MGP_CBAJ_G0030551
 protein coding gene Chr6:78187348-78367837 (-)
DBA/2J MGP_DBA2J_G0030703
 protein coding gene Chr6:69745796-69908313 (-)
FVB/NJ MGP_FVBNJ_G0030656
 protein coding gene Chr6:69139706-69303940 (-)
LP/J MGP_LPJ_G0030782
 protein coding gene Chr6:73100081-73275220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030691
 protein coding gene Chr6:81556914-81734627 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031348
 protein coding gene Chr6:72252657-72429172 (-)
PWK/PhJ MGP_PWKPhJ_G0029688
 protein coding gene Chr6:68663140-68832591 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029516
 protein coding gene Chr6:70996370-71168987 (-)
WSB/EiJ MGP_WSBEiJ_G0030054
 protein coding gene Chr6:72624567-72800664 (-)



Homology
more
  • Human Ortholog
    TCF7L1, transcription factor 7 like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF7L1, transcription factor 7 like 1
  • Synonyms
    TCF-3, TCF3
  • Links
    NCBI Gene ID: 83439
    neXtProt AC: NX_Q9HCS4
    UniProt: Q9HCS4

  • Chr Location
    2p11.2; chr2:85133392-85310387 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 6 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a targeted mutation exhibit severe embryological defects particularly affecting the cardiovascular system, nervous system, and digestive system. No homozygous embryos survive beyond E11.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1269
  • Tissues
    378
  • cDNA Data
    51
  • Literature Summary
    81
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21415 NCBI Gene Model | MGI Sequence Detail 162675 C57BL/6J ±  kb
    transcript NM_001079822 RefSeq | MGI Sequence Detail 2882 ZRU/MplStud  
    polypeptide Q9Z1J1 UniProt | EBI | MGI Sequence Detail 584 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 51
      Primer pair 6
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 81
      Gene Ontology 12
      Phenotypes 33
    • Earliest
      J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
    • Latest
      J:355647 Bugacov H, et al., Dose-dependent responses to canonical Wnt transcriptional complexes in the regulation of mammalian nephron progenitors. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory