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Dgcr6 Gene Detail
Summary
  • Symbol
    Dgcr6
  • Name
    DiGeorge syndrome critical region gene 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202877
    NCBI Gene: 13353
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17870736-17889497 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.19 cM, cytoband B2
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202877
 protein coding gene Chr16:17870724-17889497 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022600
 protein coding gene Chr16:15245999-15267464 (+)
A/J MGP_AJ_G0022561
 protein coding gene Chr16:14493214-14511885 (+)
AKR/J MGP_AKRJ_G0022538
 protein coding gene Chr16:15058937-15077948 (+)
BALB/cJ MGP_BALBcJ_G0022566
 protein coding gene Chr16:14642124-14661763 (+)
C3H/HeJ MGP_C3HHeJ_G0022333
 protein coding gene Chr16:15224186-15248234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023015
 protein coding gene Chr16:15507879-15532776 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020535
 protein coding gene Chr16:14549045-14567788 (+)
CAST/EiJ MGP_CASTEiJ_G0021860
 protein coding gene Chr16:15112491-15130997 (+)
CBA/J MGP_CBAJ_G0022302
 protein coding gene Chr16:16183604-16203447 (+)
DBA/2J MGP_DBA2J_G0022434
 protein coding gene Chr16:14403737-14424607 (+)
FVB/NJ MGP_FVBNJ_G0022409
 protein coding gene Chr16:14450285-14469005 (+)
LP/J MGP_LPJ_G0022501
 protein coding gene Chr16:15035906-15056305 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022431
 protein coding gene Chr16:15855938-15879610 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023026
 protein coding gene Chr16:14994239-15012981 (+)
PWK/PhJ MGP_PWKPhJ_G0021602
 protein coding gene Chr16:14669414-14688662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021430
 protein coding gene Chr16:14959243-14977839 (+)
WSB/EiJ MGP_WSBEiJ_G0021906
 protein coding gene Chr16:14979501-15000410 (+)



Homology
more
  • Human Ortholog
    DGCR6, DiGeorge syndrome critical region gene 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGCR6, DiGeorge syndrome critical region gene 6
  • Links
    NCBI Gene ID: 8214
    neXtProt AC: NX_Q14129
    UniProt: Q14129

  • Chr Location
    22q11.21; chr22:18906028-18914238 (+)  GRCh38
  • Human Ortholog
    DGCR6L, DiGeorge syndrome critical region gene 6 like
  • Synonyms
    DGCR6
  • Links
    NCBI Gene ID: 85359
    neXtProt AC: NX_Q9BY27
    UniProt: Q9BY27

  • Chr Location
    chr22:20314238-20320080 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    130 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    60
  • cDNA Data
    51
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13353 NCBI Gene Model | MGI Sequence Detail 18762 C57BL/6J ±  kb
transcript NM_001416778 RefSeq | MGI Sequence Detail 1865 ZRU/MplStud  
polypeptide O35347 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    Genomic 29
    cDNA 51
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2146581
References
more
  • Summaries
    All 161
    Developmental Gene Expression 5
    Diseases 6
    Phenotypes 130
  • Earliest
    J:44451 Botta A, et al., Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation. Mamm Genome. 1997 Dec;8(12):890-5
  • Latest
    J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory