Tcf7l2 Gene Detail

Summary

• Symbol
  Tcf7l2
• Name
  transcription factor 7 like 2, T cell specific, HMG box
• Synonyms
  mTcf-4B, mTcf-4E, Tcf-4, Tcf4, TCF4B, TCF4E

• Feature Type
  protein coding gene
• IDs
  MGI:1202879
  NCBI Gene: 21416
• Alliance
  gene page
• Transcription Start Sites
  79 TSS

Location &
Maps

• Sequence Map
  Chr19:55730252-55922086 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 51.59 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  4613 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1202879	protein coding gene	Chr19:55730227-55922091 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025260	protein coding gene	Chr19:56040207-56246478 (+)
A/J	MGP_AJ_G0025236	protein coding gene	Chr19:53280953-53475235 (+)
AKR/J	MGP_AKRJ_G0025205	protein coding gene	Chr19:54958379-55156863 (+)
BALB/cJ	MGP_BALBcJ_G0025231	protein coding gene	Chr19:53365863-53561311 (+)
C3H/HeJ	MGP_C3HHeJ_G0024991	protein coding gene	Chr19:55190661-55395360 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025674	protein coding gene	Chr19:57409130-57608816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023086	protein coding gene	Chr19:52212978-52409236 (+)
CAST/EiJ	MGP_CASTEiJ_G0024456	protein coding gene	Chr19:55200149-55409491 (+)
CBA/J	MGP_CBAJ_G0024971	protein coding gene	Chr19:60229824-60446792 (+)
DBA/2J	MGP_DBA2J_G0025103	protein coding gene	Chr19:53079506-53273175 (+)
FVB/NJ	MGP_FVBNJ_G0025064	protein coding gene	Chr19:52785731-52980797 (+)
LP/J	MGP_LPJ_G0025189	protein coding gene	Chr19:55905400-56115428 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025097	protein coding gene	Chr19:59595626-59800463 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025732	protein coding gene	Chr19:55178863-55381993 (+)
PWK/PhJ	MGP_PWKPhJ_G0024204	protein coding gene	Chr19:53016535-53211980 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024007	protein coding gene	Chr19:53841584-54045743 (+)
WSB/EiJ	MGP_WSBEiJ_G0024526	protein coding gene	Chr19:55300613-55503258 (+)

Homology

• Human Ortholog
  TCF7L2, transcription factor 7 like 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TCF7L2, transcription factor 7 like 2
  
• Synonyms
  TCF-4, TCF4
• Links
  HGNC:11641

  NCBI Gene ID: 6934

  neXtProt AC: NX_Q9NQB0

  UniProt: Q9NQB0

  
  
• Chr Location
  10q25.2-q25.3; chr10:112950247-113167678 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tcf7l2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: TCF7L2
• Gene Tree
  Tcf7l2
  

Human Diseases

• Diseases
  7 with human TCF7L2 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer       DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				colorectal cancer IDs colorectal cancer       DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				diabetes mellitus IDs diabetes mellitus       DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				gestational diabetes IDs gestational diabetes       DOID:11714 EFO:0004593 ICD10CM:O24.4 MESH:D016640 NCI:C34942 UMLS_CUI:C0085207
				pancreatic cancer IDs pancreatic cancer       DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463
				prostate cancer IDs prostate cancer       DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				type 2 diabetes mellitus IDs type 2 diabetes mellitus       DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  89 phenotypes from 16 alleles in 11 genetic backgrounds
  15 phenotypes from multigenic genotypes
  72 phenotype references
  

• All Mutations and Alleles
  39
• Chemically induced (ENU)
  1
• Endonuclease-mediated
  9
• Gene trapped
  11
• Targeted
  14
• Transgenic
  4
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  58 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth. Mice heterozygous for some mutations display abnormalities in glucose homeostasis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  126
• GO References
  37

Expression

• Assay Results
  1762
• Tissues
  415
• cDNA Data
  84
• Literature Summary
  162

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA TCF7L2
  Xenbase tcf7l2
  ZFIN tcf7l2

Sequences &
Gene Models

• All Sequences
  197
• RefSeq
  107
• UniProt
  14
• CCDS
  CCDS29911.1, CCDS50469.1, CCDS50470.1, CCDS50471.1, CCDS50472.1, CCDS50473.1, CCDS50474.1, CCDS89418.1

• Ensembl
  ENSMUSG00000024985 (Evidence)
• NCBI Gene
  21416

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000024985	Ensembl Gene Model | MGI Sequence Detail	191835	C57BL/6J
transcript	ENSMUST00000111657	Ensembl | MGI Sequence Detail	2135	Not Applicable
polypeptide	ENSMUSP00000107284	Ensembl | MGI Sequence Detail	598	Not Applicable

Protein
Information

• UniProt
  14 Sequences
• Protein Ontology
  PR:000016186 transcription factor 7-like 2
  (term hierarchy)
• InterPro Domains
  IPR027397 Catenin binding domain superfamily
  IPR013558 CTNNB1 binding, N-teminal
  IPR009071 High mobility group box domain
  IPR036910 High mobility group box domain superfamily
  IPR024940 Transcription factor TCF/LEF

Molecular
Reagents

• All nucleic 112

  cDNA 86

  Primer pair 16

  Other 10

  
  

  Microarray probesets 8

References

• Summaries
  All 282

  Developmental Gene Expression 162

  Gene Ontology 37

  Phenotypes 72
• Earliest
  J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
• Latest
  J:353626 Ohkawara B, et al., Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis. J Neurochem. 2024 Apr;168(4):342-354

TSS for Tcf7l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157094	Chr19:55730220-55730229 (+)	-27 bp
Tssr157095	Chr19:55730242-55730274 (+)	6 bp
Tssr157096	Chr19:55730340-55730351 (+)	94 bp
Tssr157097	Chr19:55730356-55730367 (+)	110 bp
Tssr157098	Chr19:55730488-55730498 (+)	241 bp
Tssr157099	Chr19:55730712-55730735 (+)	472 bp
Tssr157100	Chr19:55731203-55731216 (+)	958 bp
Tssr157101	Chr19:55731532-55731567 (+)	1,298 bp
Tssr157102	Chr19:55731571-55731594 (+)	1,331 bp
Tssr157103	Chr19:55731841-55731869 (+)	1,603 bp
Tssr157104	Chr19:55789337-55789341 (+)	59,087 bp
Tssr157105	Chr19:55792800-55792804 (+)	62,550 bp
Tssr157106	Chr19:55821178-55821189 (+)	90,932 bp
Tssr157107	Chr19:55821306-55821320 (+)	91,061 bp
Tssr157108	Chr19:55826260-55826263 (+)	96,010 bp
Tssr157109	Chr19:55834378-55834405 (+)	104,140 bp
Tssr157110	Chr19:55856623-55856626 (+)	126,373 bp
Tssr157111	Chr19:55874317-55874333 (+)	144,073 bp
Tssr157112	Chr19:55877364-55877375 (+)	147,118 bp
Tssr157113	Chr19:55881105-55881116 (+)	150,859 bp
Tssr157114	Chr19:55881122-55881131 (+)	150,875 bp
Tssr5560	Chr19:55881156-55881161 (+)	150,907 bp
Tssr157115	Chr19:55881172-55881176 (+)	150,922 bp
Tssr157116	Chr19:55881361-55881366 (+)	151,112 bp
Tssr157117	Chr19:55881556-55881563 (+)	151,308 bp
Tssr157118	Chr19:55881577-55881586 (+)	151,330 bp
Tssr5561	Chr19:55881642-55881646 (+)	151,392 bp
Tssr157119	Chr19:55881718-55881723 (+)	151,469 bp
Tssr157120	Chr19:55881745-55881776 (+)	151,509 bp
Tssr157121	Chr19:55881784-55881820 (+)	151,550 bp
Tssr157122	Chr19:55881825-55881830 (+)	151,576 bp
Tssr5562	Chr19:55881832-55881837 (+)	151,583 bp
Tssr157123	Chr19:55882769-55882810 (+)	152,538 bp
Tssr157124	Chr19:55882879-55882893 (+)	152,634 bp
Tssr157125	Chr19:55882904-55882907 (+)	152,654 bp
Tssr157126	Chr19:55882909-55882933 (+)	152,669 bp
Tssr157127	Chr19:55882940-55882953 (+)	152,695 bp
Tssr157128	Chr19:55883038-55883047 (+)	152,791 bp
Tssr157129	Chr19:55883346-55883359 (+)	153,101 bp
Tssr157130	Chr19:55883380-55883392 (+)	153,134 bp
Tssr157131	Chr19:55883577-55883586 (+)	153,330 bp
Tssr157132	Chr19:55883588-55883607 (+)	153,346 bp
Tssr157133	Chr19:55883629-55883656 (+)	153,391 bp
Tssr157134	Chr19:55883829-55883846 (+)	153,586 bp
Tssr157135	Chr19:55883865-55883886 (+)	153,624 bp
Tssr157136	Chr19:55883888-55883915 (+)	153,650 bp
Tssr157137	Chr19:55883922-55883929 (+)	153,674 bp
Tssr157138	Chr19:55883940-55883943 (+)	153,690 bp
Tssr157139	Chr19:55883989-55883998 (+)	153,742 bp
Tssr157140	Chr19:55884002-55884013 (+)	153,756 bp
Tssr157141	Chr19:55884014-55884023 (+)	153,767 bp
Tssr157142	Chr19:55884847-55884852 (+)	154,598 bp
Tssr157143	Chr19:55886345-55886363 (+)	156,102 bp
Tssr157144	Chr19:55886373-55886382 (+)	156,126 bp
Tssr157145	Chr19:55886383-55886398 (+)	156,139 bp
Tssr157146	Chr19:55886695-55886706 (+)	156,449 bp
Tssr157147	Chr19:55886709-55886721 (+)	156,463 bp
Tssr157148	Chr19:55887028-55887038 (+)	156,781 bp
Tssr157149	Chr19:55887377-55887410 (+)	157,142 bp
Tssr157150	Chr19:55896865-55896911 (+)	166,636 bp
Tssr157151	Chr19:55896937-55896949 (+)	166,691 bp
Tssr157152	Chr19:55898991-55899009 (+)	168,748 bp
Tssr157153	Chr19:55899016-55899027 (+)	168,770 bp
Tssr157154	Chr19:55899063-55899084 (+)	168,822 bp
Tssr157155	Chr19:55901021-55901040 (+)	170,779 bp
Tssr157156	Chr19:55905780-55905794 (+)	175,535 bp
Tssr157157	Chr19:55905799-55905809 (+)	175,552 bp
Tssr157158	Chr19:55907934-55907950 (+)	177,690 bp
Tssr157159	Chr19:55914365-55914379 (+)	184,120 bp
Tssr157160	Chr19:55914383-55914411 (+)	184,145 bp
Tssr157161	Chr19:55918901-55918907 (+)	188,652 bp
Tssr157162	Chr19:55919896-55919912 (+)	189,652 bp
Tssr157163	Chr19:55919929-55919962 (+)	189,694 bp
Tssr157164	Chr19:55920135-55920148 (+)	189,890 bp
Tssr157165	Chr19:55920731-55920757 (+)	190,492 bp
Tssr157166	Chr19:55920807-55920811 (+)	190,557 bp
Tssr157167	Chr19:55920922-55920935 (+)	190,677 bp
Tssr157168	Chr19:55921174-55921178 (+)	190,924 bp
Tssr157169	Chr19:55921604-55921615 (+)	191,358 bp