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Cuzd1 Gene Detail
Summary
  • Symbol
    Cuzd1
  • Name
    CUB and zona pellucida-like domains 1
  • Synonyms
    ERG-1, Itmap1, UO-44, UTCZP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202881
    NCBI Gene: 16433
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:130910283-130924021 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 73.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202881
 protein coding gene Chr7:130910283-130924021 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033099
 protein coding gene Chr7:135927074-135944578 (-)
A/J MGP_AJ_G0033081
 protein coding gene Chr7:132217955-132232986 (-)
AKR/J MGP_AKRJ_G0033013
 protein coding gene Chr7:135725234-135740698 (-)
BALB/cJ MGP_BALBcJ_G0033082
 protein coding gene Chr7:131907823-131921603 (-)
C3H/HeJ MGP_C3HHeJ_G0032796
 protein coding gene Chr7:135579371-135596210 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033593
 protein coding gene Chr7:141111023-141126279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030564
 protein coding gene Chr7:133499035-133512409 (-)
CAST/EiJ MGP_CASTEiJ_G0032126
 protein coding gene Chr7:127432125-127448235 (-)
CBA/J MGP_CBAJ_G0032769
 protein coding gene Chr7:146009442-146022729 (-)
DBA/2J MGP_DBA2J_G0032921
 protein coding gene Chr7:130202721-130216400 (-)
FVB/NJ MGP_FVBNJ_G0032874
 protein coding gene Chr7:130070135-130083544 (-)
LP/J MGP_LPJ_G0033015
 protein coding gene Chr7:137423609-137439605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032906
 protein coding gene Chr7:146933149-146946994 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033613
 protein coding gene Chr7:134721069-134738470 (-)
PWK/PhJ MGP_PWKPhJ_G0031832
 protein coding gene Chr7:123240358-123254809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031678
 protein coding gene Chr7:121497899-121511309 (-)
WSB/EiJ MGP_WSBEiJ_G0032237
 protein coding gene Chr7:135622525-135637181 (-)



Homology
more
  • Human Ortholog
    CUZD1, CUB and zona pellucida like domains 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUZD1, CUB and zona pellucida like domains 1
  • Synonyms
    ERG-1, ERG1, ITMAP1, UO-44
  • Links
    NCBI Gene ID: 50624
    neXtProt AC: NX_Q86UP6
    UniProt: Q86UP6

  • Chr Location
    10q26.13; chr10:122832158-122846175 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for disruption of this gene exhibit impaired mammary gland development during puberty and during and following pregnancy and do not lactate. Homozygous mutant mice show an increased susceptibility to induced pancreatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16433 NCBI Gene Model | MGI Sequence Detail 13739 C57BL/6J ±  kb
    transcript NM_008411 RefSeq | MGI Sequence Detail 2270 C57BL/6  
    polypeptide P70412 UniProt | EBI | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:46397 Kasik JW, A cDNA cloned from pregnant mouse uterus exhibits temporo-spatial expression and predicts a novel protein. Biochem J. 1998 Mar 1;330(Pt 2):947-50
    • Latest
      J:305792 Ansarullah, et al., Inceptor counteracts insulin signalling in beta-cells to control glycaemia. Nature. 2021 Feb;590(7845):326-331
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory