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Meg3 Gene Detail
Summary
  • Symbol
    Meg3
  • Name
    maternally expressed 3
  • Synonyms
    2900016C05Rik, 3110050O07Rik, 6330408G06Rik, D12Bwg1266e, Gtl2
  • Feature Type
    lncRNA gene
  • IDs
    MGI:1202886
    NCBI Gene: 17263
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:109506879-109538163 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.25 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202886
 lncRNA gene Chr12:109506879-109538165 (+)
129S1/SvImJ MGP_129S1SvImJ_G0005408
 lincRNA gene Chr12:111766233-111800327 (+)
A/J MGP_AJ_G0005391
 lincRNA gene Chr12:107461904-107494902 (+)
AKR/J MGP_AKRJ_G0005371
 lincRNA gene Chr12:110596834-110631831 (+)
BALB/cJ MGP_BALBcJ_G0005373
 lincRNA gene Chr12:107934756-107968286 (+)
C3H/HeJ MGP_C3HHeJ_G0005322
 lincRNA gene Chr12:111040006-111073237 (+)
C57BL/6NJ MGP_C57BL6NJ_G0005527
 lincRNA gene Chr12:115182257-115219843 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0004912
 lincRNA gene Chr12:103989695-104020888 (+)
CAST/EiJ MGP_CASTEiJ_G0005266
 lincRNA gene Chr12:105987297-106024589 (+)
CBA/J MGP_CBAJ_G0005311
 lincRNA gene Chr12:119726418-119759298 (+)
DBA/2J MGP_DBA2J_G0005328
 lincRNA gene Chr12:107018650-107049871 (+)
FVB/NJ MGP_FVBNJ_G0005354
 lincRNA gene Chr12:105807160-105840547 (+)
LP/J MGP_LPJ_G0005410
 lincRNA gene Chr12:111594044-111627488 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0005336
 lincRNA gene Chr12:122874292-122909657 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0005528
 lincRNA gene Chr12:110076028-110111722 (+)
PWK/PhJ MGP_PWKPhJ_G0005215
 lincRNA gene Chr12:101624362-101657367 (+)
SPRET/EiJ MGP_SPRETEiJ_G0005136
 lincRNA gene Chr12:104247644-104279722 (+)
WSB/EiJ MGP_WSBEiJ_G0005316
 lincRNA gene Chr12:110990636-111026559 (+)



Homology
more
  • Human Ortholog
    MEG3, maternally expressed 3
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEG3, maternally expressed 3
  • Synonyms
    FP504, GTL2, LINC00023, NCRNA00023, onco-lncRNA-83, prebp1, PRO0518, PRO2160
  • Links
    NCBI Gene ID: 55384

  • Chr Location
    14q32.2; chr14:100779410-100861031 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for disruptions in this gene show lethality and growth retardation that are dependent on the parental origin of the allele and the extent of the deletion of the associated differentially methylated region.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1244
  • Tissues
    230
  • cDNA Data
    78
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      133
    • RefSeq
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17263 NCBI Gene Model | MGI Sequence Detail 31285 C57BL/6J ±  kb
    transcript NR_003633 RefSeq | MGI Sequence Detail 11488 ZRU/MplStud  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 127
      Genomic 8
      cDNA 86
      Primer pair 32
      Other 1

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-32136, MGD-MRK-34035, MGI:105096, MGI:106343, MGI:1914508, MGI:1914551, MGI:1917961, MGI:2144809, MGI:2145004, MGI:2145132, MGI:2145137
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 62
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:30839 Schuster-Gossler K, et al., Gtl2lacZ, an insertional mutation on mouse chromosome 12 with parental origin-dependent phenotype. Mamm Genome. 1996 Jan;7(1):20-4
    • Latest
      J:348979 Cheng X, et al., Multifaceted roles of Meg3 in cellular senescence and atherosclerosis. Atherosclerosis. 2024 May;392:117506
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory