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Sema6b Gene Detail
Summary
  • Symbol
    Sema6b
  • Name
    sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
  • Synonyms
    Sema, Seman, semaZ, VIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202889
    NCBI Gene: 20359
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56430085-56447343 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.17 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202889
 protein coding gene Chr17:56430085-56447343 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023915
 protein coding gene Chr17:57770513-57790929 (-)
A/J MGP_AJ_G0023874
 protein coding gene Chr17:56213232-56230488 (-)
AKR/J MGP_AKRJ_G0023844
 protein coding gene Chr17:56884155-56901361 (-)
BALB/cJ MGP_BALBcJ_G0023876
 protein coding gene Chr17:56036523-56053825 (-)
C3H/HeJ MGP_C3HHeJ_G0023639
 protein coding gene Chr17:57596969-57614213 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024320
 protein coding gene Chr17:60053481-60072484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021767
 protein coding gene Chr17:52709089-52727242 (-)
CAST/EiJ MGP_CASTEiJ_G0023122
 protein coding gene Chr17:57908835-57926247 (-)
CBA/J MGP_CBAJ_G0023616
 protein coding gene Chr17:62351906-62369234 (-)
DBA/2J MGP_DBA2J_G0023744
 protein coding gene Chr17:54928495-54945823 (-)
FVB/NJ MGP_FVBNJ_G0023710
 protein coding gene Chr17:54448860-54468311 (-)
LP/J MGP_LPJ_G0023824
 protein coding gene Chr17:58474989-58492294 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023737
 protein coding gene Chr17:61905442-61922705 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024365
 protein coding gene Chr17:57260684-57275733 (-)
PWK/PhJ MGP_PWKPhJ_G0022867
 protein coding gene Chr17:54274933-54292991 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022679
 protein coding gene Chr17:54028598-54045801 (-)
WSB/EiJ MGP_WSBEiJ_G0023186
 protein coding gene Chr17:57874707-57891955 (-)



Homology
more
  • Human Ortholog
    SEMA6B, semaphorin 6B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA6B, semaphorin 6B
  • Synonyms
    EPM11, SEMAN, SEMA-VIB, semaZ, SEM-SEMA-Y, SEM-SEMA-Z
  • Links
    NCBI Gene ID: 10501
    neXtProt AC: NX_Q9H3T3
    UniProt: Q9H3T3

  • Chr Location
    19p13.3; chr19:4542593-4581776 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SEMA6B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mossy fiber and mossy cell axon projections, thickened suprapyramidal bundles, and elongated infrapyramydal bundles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    25
  • cDNA Data
    19
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20359 NCBI Gene Model | MGI Sequence Detail 17259 C57BL/6J ±  kb
    transcript NM_013662 RefSeq | MGI Sequence Detail 3847 C57BL/6  
    polypeptide O54951 UniProt | EBI | MGI Sequence Detail 886 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 20
      Other 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 16
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:46042 Eckhardt F, et al., A novel transmembrane semaphorin can bind c-src. Mol Cell Neurosci. 1997;9(5-6):409-19
    • Latest
      J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory