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Cd46 Gene Detail
Summary
  • Symbol
    Cd46
  • Name
    CD46 antigen, complement regulatory protein
  • Synonyms
    CD46, Mcp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203290
    NCBI Gene: 17221
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:194719134-194774557 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    752 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203290
 protein coding gene Chr1:194719134-194781149 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016967
 protein coding gene Chr1:202218351-202267177 (-)
A/J MGP_AJ_G0016946
 protein coding gene Chr1:193915469-193963431 (-)
AKR/J MGP_AKRJ_G0016911
 protein coding gene Chr1:199650475-199704288 (-)
BALB/cJ MGP_BALBcJ_G0016904
 protein coding gene Chr1:194618704-194664757 (-)
C3H/HeJ MGP_C3HHeJ_G0016728
 protein coding gene Chr1:200544249-200596216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017367
 protein coding gene Chr1:208587020-208645472 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015074
 protein coding gene Chr1:185313524-185357433 (-)
CAST/EiJ MGP_CASTEiJ_G0016311
 protein coding gene Chr1:200106515-200153206 (-)
CBA/J MGP_CBAJ_G0016702
 protein coding gene Chr1:216282628-216340655 (-)
DBA/2J MGP_DBA2J_G0016808
 protein coding gene Chr1:192642922-192685391 (-)
FVB/NJ MGP_FVBNJ_G0016804
 protein coding gene Chr1:190721998-190777766 (-)
LP/J MGP_LPJ_G0016883
 protein coding gene Chr1:203359823-203399901 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016836
 protein coding gene Chr1:222929823-222989799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017404
 protein coding gene Chr1:199505717-199548259 (-)
PWK/PhJ MGP_PWKPhJ_G0016098
 protein coding gene Chr1:191945549-191993083 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015874
 protein coding gene Chr1:198548434-198595176 (-)
WSB/EiJ MGP_WSBEiJ_G0016373
 protein coding gene Chr1:199781697-199831063 (-)



Homology
more
  • Human Ortholog
    CD46, CD46 molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD46, CD46 molecule
  • Synonyms
    AHUS2, MCP, MIC10, TLX, TRA2.10
  • Links
    NCBI Gene ID: 4179
    neXtProt AC: NX_P15529
    UniProt: P15529

  • Chr Location
    1q32.2; chr1:207752037-207795516 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cd46 mouse models; 6 with human CD46 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased litter sizes sired by mutant males. Another homozygous null mouse shows increased susceptibility to induced choroid neovascularization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    4
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016493 Ensembl Gene Model | MGI Sequence Detail 55424 C57BL/6J ±  kb
    transcript ENSMUST00000162650 Ensembl | MGI Sequence Detail 6288 Not Applicable  
    polypeptide ENSMUSP00000123931 Ensembl | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:46287 Tsujimura A, et al., Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells. Biochem J. 1998 Feb 15;330(Pt 1):163-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory