About   Help   FAQ
Map3k19 Gene Detail
Summary
  • Symbol
    Map3k19
  • Name
    mitogen-activated protein kinase kinase kinase 19
  • Synonyms
    Ysk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203481
    NCBI Gene: 22625
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:127742528-127782768 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 55.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203481
 protein coding gene Chr1:127741217-127782768 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016423
 protein coding gene Chr1:131036571-131073716 (-)
A/J MGP_AJ_G0016406
 protein coding gene Chr1:126153590-126192274 (-)
AKR/J MGP_AKRJ_G0016371
 protein coding gene Chr1:129865997-129903097 (-)
BALB/cJ MGP_BALBcJ_G0016366
 protein coding gene Chr1:126532009-126572183 (-)
C3H/HeJ MGP_C3HHeJ_G0016192
 protein coding gene Chr1:130050200-130089753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016827
 protein coding gene Chr1:135963019-136002916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014540
 protein coding gene Chr1:119513340-119554321 (-)
CAST/EiJ MGP_CASTEiJ_G0015773
 protein coding gene Chr1:129015961-129057228 (-)
CBA/J MGP_CBAJ_G0016165
 protein coding gene Chr1:140547329-140593625 (-)
DBA/2J MGP_DBA2J_G0016271
 protein coding gene Chr1:125190418-125232149 (-)
FVB/NJ MGP_FVBNJ_G0016270
 protein coding gene Chr1:123908620-123944087 (-)
LP/J MGP_LPJ_G0016342
 protein coding gene Chr1:132388279-132425105 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016295
 protein coding gene Chr1:146412359-146451856 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016863
 protein coding gene Chr1:129657745-129697440 (-)
PWK/PhJ MGP_PWKPhJ_G0015559
 protein coding gene Chr1:124163016-124206023 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015347
 protein coding gene Chr1:128609385-128648677 (-)
WSB/EiJ MGP_WSBEiJ_G0015835
 protein coding gene Chr1:129607966-129652524 (-)



Homology
more
  • Human Ortholog
    MAP3K19, mitogen-activated protein kinase kinase kinase 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K19, mitogen-activated protein kinase kinase kinase 19
  • Synonyms
    RCK, YSK4
  • Links
    NCBI Gene ID: 80122
    neXtProt AC: NX_Q56UN5
    UniProt: Q56UN5

  • Chr Location
    2q21.3; chr2:134964485-135047468 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Genomic Mutations
    3 involving Map3k19
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    57 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    9
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051590 Ensembl Gene Model | MGI Sequence Detail 40241 C57BL/6J ±  kb
transcript ENSMUST00000208183 Ensembl | MGI Sequence Detail 5345 Not Applicable  
polypeptide ENSMUSP00000146463 Ensembl | MGI Sequence Detail 1515 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000017548 mitogen-activated protein kinase kinase kinase 19
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR050538 Mitogen-activated protein kinase kinase kinase
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
  • GlyGen
    E9Q3S4 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory