Zfp638 MGI Mouse Gene Detail - MGI:1203484

Symbol

Zfp638
Name

zinc finger protein 638
Synonyms

Np220, Zfml

Feature Type

protein coding gene
IDs

MGI:1203484
NCBI Gene: 18139
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:83844050-83963855 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 36.06 cM
Mapping Data

1 experiment

SNPs within 2kb

1746 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1203484	protein coding gene	Chr6:83844050-83966532 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030943	protein coding gene	Chr6:84909194-85038853 (+)
A/J	MGP_AJ_G0030912	protein coding gene	Chr6:81674213-81795899 (+)
AKR/J	MGP_AKRJ_G0030840	protein coding gene	Chr6:84036502-84164622 (+)
BALB/cJ	MGP_BALBcJ_G0030922	protein coding gene	Chr6:81702535-81824645 (+)
C3H/HeJ	MGP_C3HHeJ_G0030788	protein coding gene	Chr6:100251431-100374030 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031382	protein coding gene	Chr6:87255341-87383761 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028568	protein coding gene	Chr6:80040894-80165159 (+)
CAST/EiJ	MGP_CASTEiJ_G0030031	protein coding gene	Chr6:84061290-84186865 (+)
CBA/J	MGP_CBAJ_G0030609	protein coding gene	Chr6:90680248-90819084 (+)
DBA/2J	MGP_DBA2J_G0030762	protein coding gene	Chr6:80986714-81109980 (+)
FVB/NJ	MGP_FVBNJ_G0030715	protein coding gene	Chr6:80199441-80322978 (+)
LP/J	MGP_LPJ_G0030841	protein coding gene	Chr6:84912329-85038066 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030751	protein coding gene	Chr6:94950628-95099386 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031406	protein coding gene	Chr6:83863600-83989540 (+)
PWK/PhJ	MGP_PWKPhJ_G0029746	protein coding gene	Chr6:79899978-80024333 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029574	protein coding gene	Chr6:82690940-82815199 (+)
WSB/EiJ	MGP_WSBEiJ_G0030112	protein coding gene	Chr6:84287797-84412774 (+)

Human Ortholog

ZNF638, zinc finger protein 638

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF638, zinc finger protein 638
Synonyms

NP220, ZFML, Zfp638
Links

HGNC:17894

NCBI Gene ID: 27332

neXtProt AC: NX_Q14966

UniProt: Q14966
Chr Location

2p13.2; chr2:71276561-71435069 (+) GRCh38

MGI Vertebrate Homology

Zfp638 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF638
Gene Tree

Zfp638

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Endonuclease-mediated

5
Gene trapped

28
Spontaneous

1
Genomic Mutations

2 involving Zfp638
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

54
cDNA Data

167
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ZNF638

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All Sequences

163
RefSeq

80
UniProt

15
CCDS

CCDS20288.1, CCDS51823.1

Ensembl

ENSMUSG00000030016 (Evidence)
NCBI Gene

18139

			Length	Strain/Species	Flank
genomic	18139	NCBI Gene Model \| MGI Sequence Detail	119806	C57BL/6J	± kb
transcript	NM_001406074	RefSeq \| MGI Sequence Detail	6444	C57BL/6
polypeptide	Q61464	UniProt \| EBI \| MGI Sequence Detail	1960	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000018045 zinc finger protein 638

(term hierarchy)
InterPro Domains

IPR026811 Cip1-interacting zinc finger protein

IPR000690 Matrin/U1-C, C2H2-type zinc finger

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

IPR022755 Zinc finger, double-stranded RNA binding

IPR033096 Zinc finger protein 638, RNA recognition motif 1/2
GlyGen

Q61464 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 169

cDNA 167

Primer pair 2

Microarray probesets 5

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MGI:2141390

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 15
Earliest

J:33575 Matsushima Y, et al., A family of novel DNA-binding nuclear proteins having polypyrimidine tract-binding motif and arginine/serine-rich motif. Biochem Biophys Res Commun. 1996 Jun 14;223(2):427-33
Latest

J:346397 Meng M, et al., Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner. Metabolism. 2024 Jan 9;152:155784

TSS for Zfp638:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57384	Chr6:83844085-83844107 (+)	46 bp
Tssr57385	Chr6:83844114-83844125 (+)	70 bp
Tssr57386	Chr6:83844399-83844405 (+)	352 bp
Tssr57387	Chr6:83891336-83891393 (+)	47,315 bp
Tssr57388	Chr6:83930855-83930858 (+)	86,807 bp
Tssr57389	Chr6:83955270-83955275 (+)	111,223 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24