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Mgam Gene Detail
Summary
  • Symbol
    Mgam
  • Name
    maltase-glucoamylase
  • Synonyms
    6030407P20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203495
    NCBI Gene: 232714
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:40605765-40746057 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 18.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3193 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203495
 protein coding gene Chr6:40605765-40746057 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030616
 protein coding gene Chr6:39077384-39234250 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0030516
 protein coding gene Chr6:38552644-38711606 (+)
BALB/cJ MGP_BALBcJ_G0030599
 protein coding gene Chr6:37590511-37739971 (+)
C3H/HeJ MGP_C3HHeJ_G0030312
 protein coding gene Chr6:38565877-38728702 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031053
 protein coding gene Chr6:40056255-40221974 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028265
 protein coding gene Chr6:35232426-35363257 (+)
CAST/EiJ MGP_CASTEiJ_G0029714
 protein coding gene Chr6:38497023-38650865 (+)
CBA/J MGP_CBAJ_G0030290
 protein coding gene Chr6:41664756-41843766 (+)
DBA/2J MGP_DBA2J_G0030434
 protein coding gene Chr6:37191481-37338441 (+)
FVB/NJ MGP_FVBNJ_G0030388
 protein coding gene Chr6:36960177-37102121 (+)
LP/J MGP_LPJ_G0030521
 protein coding gene Chr6:39095393-39251324 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030424
 protein coding gene Chr6:43914296-44080660 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0029264
 protein coding gene Chr6:38241097-38397259 (+)
WSB/EiJ MGP_WSBEiJ_G0029790
 protein coding gene Chr6:38471947-38625588 (+)



Homology
more
  • Human Ortholog
    MGAM, maltase-glucoamylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGAM, maltase-glucoamylase
  • Synonyms
    MG, MGA
  • Links
    NCBI Gene ID: 8972
    neXtProt AC: NX_O43451
    UniProt: O43451

  • Chr Location
    7q34; chr7:141907813-142106747 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display abnormalities in starch digestion and prandial glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    96
  • cDNA Data
    5
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232714 NCBI Gene Model | MGI Sequence Detail 140293 C57BL/6J ±  kb
    transcript NM_001368875 RefSeq | MGI Sequence Detail 11854 C57BL/6  
    polypeptide NP_001355804 RefSeq | MGI Sequence Detail 3616 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
      3.2.1.20, 3.2.1.3
    • InterPro Domains
      IPR011013 Galactose mutarotase-like domain superfamily
      IPR025887 Glycoside hydrolase family 31, N-terminal domain
      IPR000322 Glycoside hydrolase family 31, TIM barrel domain
      IPR017853 Glycoside hydrolase superfamily
      IPR013780 Glycosyl hydrolase, all-beta
      IPR048395 Glycosyl hydrolase family 31, C-terminal domain
      IPR030458 Glycosyl hydrolases family 31, active site
      IPR030459 Glycosyl hydrolases family 31, conserved site
      IPR000519 P-type trefoil domain
      IPR044913 P-type trefoil domain superfamily
    • GlyGen
      A0A571BF69 8 sites, 8 N-linked glycans (8 sites)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2442777
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 3
    • Earliest
      J:45511 Nichols BL, et al., Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. J Biol Chem. 1998 Jan 30;273(5):3076-81
    • Latest
      J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory