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Magi1 Gene Detail
Summary
  • Symbol
    Magi1
  • Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1
  • Synonyms
    AIP3, Baiap1, BAP1, Gukmi1, WWP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203522
    NCBI Gene: 14924
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:93652436-94260898 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 42.70 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16912 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203522
 protein coding gene Chr6:93652434-94260906 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031063
 protein coding gene Chr6:95392171-96027614 (-)
A/J MGP_AJ_G0031032
 protein coding gene Chr6:91763932-92385679 (-)
AKR/J MGP_AKRJ_G0030963
 protein coding gene Chr6:94294540-94915401 (-)
BALB/cJ MGP_BALBcJ_G0031043
 protein coding gene Chr6:91721728-92337002 (-)
C3H/HeJ MGP_C3HHeJ_G0030665
 protein coding gene Chr6:89508597-90146346 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031502
 protein coding gene Chr6:97816481-98452352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028668
 protein coding gene Chr6:89721849-90351667 (-)
CAST/EiJ MGP_CASTEiJ_G0030150
 protein coding gene Chr6:94454233-95114684 (-)
CBA/J MGP_CBAJ_G0030729
 protein coding gene Chr6:101490475-102163425 (-)
DBA/2J MGP_DBA2J_G0030882
 protein coding gene Chr6:90918646-91530125 (-)
FVB/NJ MGP_FVBNJ_G0030836
 protein coding gene Chr6:90139424-90753898 (-)
LP/J MGP_LPJ_G0030962
 protein coding gene Chr6:95356011-96011199 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030870
 protein coding gene Chr6:105481890-106130617 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031529
 protein coding gene Chr6:94154024-94795386 (-)
PWK/PhJ MGP_PWKPhJ_G0029866
 protein coding gene Chr6:89907939-90531642 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029695
 protein coding gene Chr6:93097193-93725119 (-)
WSB/EiJ MGP_WSBEiJ_G0030234
 protein coding gene Chr6:94621485-95257567 (-)



Homology
more
  • Human Ortholog
    MAGI1, membrane associated guanylate kinase, WW and PDZ domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGI1, membrane associated guanylate kinase, WW and PDZ domain containing 1
  • Synonyms
    AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, MAGI-1b, Magi1d, TNRC19, WWP3
  • Links
    NCBI Gene ID: 9223
    neXtProt AC: NX_Q96QZ7
    UniProt: Q96QZ7

  • Chr Location
    3p14.1; chr3:65353525-66038918 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    19
  • cDNA Data
    103
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045095 Ensembl Gene Model | MGI Sequence Detail 608463 C57BL/6J ±  kb
transcript ENSMUST00000089317 Ensembl | MGI Sequence Detail 7209 Not Applicable  
polypeptide ENSMUSP00000086730 Ensembl | MGI Sequence Detail 1471 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 107
    Genomic 2
    cDNA 104
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 57
    Developmental Gene Expression 5
    Gene Ontology 13
    Phenotypes 18
  • Earliest
    J:44633 Dobrosotskaya I, et al., MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. J Biol Chem. 1997 Dec 12;272(50):31589-97
  • Latest
    J:329292 Wang Y, et al., MAGI1 inhibits interferon signaling to promote influenza A infection. Front Cardiovasc Med. 2022;9:791143
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory