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Dtnb Gene Detail
Summary
  • Symbol
    Dtnb
  • Name
    dystrobrevin, beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203728
    NCBI Gene: 13528
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:3622381-3831796 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 1.88 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4840 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203728
 protein coding gene Chr12:3622372-3834070 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019558
 protein coding gene Chr12:387954-616377 (+)
A/J MGP_AJ_G0019525
 protein coding gene Chr12:441473-654793 (+)
AKR/J MGP_AKRJ_G0019495
 protein coding gene Chr12:569924-792517 (+)
BALB/cJ MGP_BALBcJ_G0019500
 protein coding gene Chr12:468324-680976 (+)
C3H/HeJ MGP_C3HHeJ_G0019306
 protein coding gene Chr12:350364-570362 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019950
 protein coding gene Chr12:408469-628701 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017574
 protein coding gene Chr12:382764-578363 (+)
CAST/EiJ MGP_CASTEiJ_G0018861
 protein coding gene Chr12:409411-631548 (+)
CBA/J MGP_CBAJ_G0019277
 protein coding gene Chr12:626497-869170 (+)
DBA/2J MGP_DBA2J_G0019390
 protein coding gene Chr12:393427-599181 (+)
FVB/NJ MGP_FVBNJ_G0019381
 protein coding gene Chr12:414255-621504 (+)
LP/J MGP_LPJ_G0019461
 protein coding gene Chr12:418894-642394 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019414
 protein coding gene Chr12:453373-688807 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019988
 protein coding gene Chr12:354371-571248 (+)
PWK/PhJ MGP_PWKPhJ_G0018627
 protein coding gene Chr12:403500-607383 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018418
 protein coding gene Chr12:428322-658925 (+)
WSB/EiJ MGP_WSBEiJ_G0018913
 protein coding gene Chr12:382819-605378 (+)



Homology
more
  • Human Ortholog
    DTNB, dystrobrevin beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTNB, dystrobrevin beta
  • Links
    NCBI Gene ID: 1838
    neXtProt AC: NX_O60941
    UniProt: O60941

  • Chr Location
    2p23.3; chr2:25377198-25673647 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and show no obvious histological or functional abnormalities in liver and kidney. Mice homozygous for a gene trapped allele are viable, fertile and overtly normal with no significant synaptic or behavioral defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    61
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071454 Ensembl Gene Model | MGI Sequence Detail 209416 C57BL/6J ±  kb
transcript ENSMUST00000164578 Ensembl | MGI Sequence Detail 2355 Not Applicable  
polypeptide ENSMUSP00000126194 Ensembl | MGI Sequence Detail 659 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 1
    cDNA 63
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Developmental Gene Expression 1
    Gene Ontology 17
    Phenotypes 12
  • Earliest
    J:46808 Puca AA, et al., Identification and characterization of a novel member of the dystrobrevin gene family. FEBS Lett. 1998 Mar 20;425(1):7-13
  • Latest
    J:352582 Fujimoto T, et al., Generation of dystrophin short product-specific tag-insertion mouse: distinct Dp71 glycoprotein complexes at inhibitory postsynapse and glia limitans. Cell Mol Life Sci. 2022 Jan 30;79(2):109
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory