Pik3c2g MGI Mouse Gene Detail - MGI:1203730 - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

Symbol

Pik3c2g
Name

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

Feature Type

protein coding gene
IDs

MGI:1203730
NCBI Gene: 18705
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr6:139591070-139915010 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 69.70 cM
Mapping Data

3 experiments

SNPs within 2kb

11061 from dbSNP Build 142
Strain Annotations

10
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1203730	protein coding gene	Chr6:139564219-139915010 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031444	protein coding gene	Chr6:144264930-144639775 (+)
A/J	MGP_AJ_G0031419	protein coding gene	Chr6:138542734-138891995 (+)
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0029017	protein coding gene	Chr6:137492090-137824457 (+)
CAST/EiJ	MGP_CASTEiJ_G0030516	protein coding gene	Chr6:142328204-142697677 (+)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0031256	protein coding gene	Chr6:157765356-158142219 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031920	protein coding gene	Chr6:142513461-142882674 (+)
PWK/PhJ	MGP_PWKPhJ_G0030243	protein coding gene	Chr6:135898445-136257988 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030067	protein coding gene	Chr6:140759057-141116855 (+)
WSB/EiJ	MGP_WSBEiJ_G0030609	protein coding gene	Chr6:143170882-143531487 (+)

Human Ortholog

PIK3C2G, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIK3C2G, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Synonyms

PI3K-C2-gamma, PI3K-C2GAMMA
Links

HGNC:8973

NCBI Gene ID: 5288

neXtProt AC: NX_O75747

UniProt: O75747
Chr Location

12p12.3; chr12:18242961-18726817 (+) GRCh38

MGI Vertebrate Homology

Pik3c2g stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIK3C2G
Gene Tree

Pik3c2g

Diseases

1 with human PIK3C2G associations

				Human Disease	Mouse Models
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

106
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

59
RefSeq

4
UniProt

9
CCDS

CCDS80630.1

Ensembl

ENSMUSG00000030228 (Evidence)
NCBI Gene

18705

			Length	Strain/Species	Flank
genomic	18705	NCBI Gene Model \| MGI Sequence Detail	323941	C57BL/6J	± kb
transcript	NM_207683	RefSeq \| MGI Sequence Detail	6280	ZRU/MplStud
polypeptide	O70167	UniProt \| EBI \| MGI Sequence Detail	1506	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000012717 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

(term hierarchy)
EC

2.7.1.137, 2.7.1.154
InterPro Domains

IPR016024 Armadillo-type fold

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR002420 C2 phosphatidylinositol 3-kinase-type domain

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain

IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

IPR018936 Phosphatidylinositol 3/4-kinase, conserved site

IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain

IPR015433 Phosphatidylinositol kinase

IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain

IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

IPR001683 Phox homology

IPR037707 PI3K-C2-gamma, catalytic domain

IPR011009 Protein kinase-like domain superfamily

IPR036871 PX domain superfamily

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 3

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MGI:2141760

Summaries

All 34

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 2
Earliest

J:46628 Misawa H, et al., Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem Biophys Res Commun. 1998 Mar 17;244(2):531-9
Latest

J:287213 Scortegagna M, et al., The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion. JCI Insight. 2017 Dec 7;2(23)

TSS for Pik3c2g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59405	Chr6:139639682-139639694 (+)	48,618 bp
Tssr59406	Chr6:139787378-139787384 (+)	196,311 bp
Tssr59407	Chr6:139842437-139842440 (+)	251,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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