Cacng1 MGI Mouse Gene Detail - MGI:1206582 - calcium channel, voltage-dependent, gamma subunit 1

Symbol

Cacng1
Name

calcium channel, voltage-dependent, gamma subunit 1

Feature Type

protein coding gene
IDs

MGI:1206582
NCBI Gene: 12299
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:107594044-107607302 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 70.29 cM, cytoband E1
Mapping Data

1 experiment

SNPs within 2kb

548 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1206582	protein coding gene	Chr11:107594044-107607348 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019322	protein coding gene	Chr11:111123797-111137072 (-)
A/J	MGP_AJ_G0019290	protein coding gene	Chr11:106355263-106368548 (-)
AKR/J	MGP_AKRJ_G0019259	protein coding gene	Chr11:109534728-109548021 (-)
BALB/cJ	MGP_BALBcJ_G0019264	protein coding gene	Chr11:106775886-106789181 (-)
C3H/HeJ	MGP_C3HHeJ_G0019073	protein coding gene	Chr11:109848916-109862201 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019714	protein coding gene	Chr11:114553714-114567098 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017338	protein coding gene	Chr11:103617166-103630413 (-)
CAST/EiJ	MGP_CASTEiJ_G0018626	protein coding gene	Chr11:110947927-110962477 (-)
CBA/J	MGP_CBAJ_G0019042	protein coding gene	Chr11:119284664-119300696 (-)
DBA/2J	MGP_DBA2J_G0019154	protein coding gene	Chr11:105832810-105846346 (-)
FVB/NJ	MGP_FVBNJ_G0019145	protein coding gene	Chr11:105340184-105353449 (-)
LP/J	MGP_LPJ_G0019224	protein coding gene	Chr11:111568306-111581584 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019175	protein coding gene	Chr11:118501902-118515183 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019751	protein coding gene	Chr11:110087329-110100742 (-)
PWK/PhJ	MGP_PWKPhJ_G0018391	protein coding gene	Chr11:106978673-106992321 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018182	protein coding gene	Chr11:109850905-109865968 (-)
WSB/EiJ	MGP_WSBEiJ_G0018677	protein coding gene	Chr11:110035572-110048911 (-)

Human Ortholog

CACNG1, calcium voltage-gated channel auxiliary subunit gamma 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CACNG1, calcium voltage-gated channel auxiliary subunit gamma 1
Synonyms

CACNLG
Links

HGNC:1405

NCBI Gene ID: 786

neXtProt AC: NX_Q06432

UniProt: Q06432
Chr Location

17q24.2; chr17:67044554-67056797 (+) GRCh38

MGI Vertebrate Homology

Cacng1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CACNG1
Gene Tree

Cacng1

Diseases

1 with human CACNG1 associations

				Human Disease	Mouse Models
				malignant hyperthermia IDs malignant hyperthermia DOID:8545 ICD10CM:T88.3 ICD9CM:995.86 MESH:D008305 NCI:C84869 OMIM:PS145600 ORDO:423 UMLS_CUI:C0024591

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for null mutations display abnormal muscle calcium currents.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

29
cDNA Data

26
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CACNG1

Xenbase cacng1

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All Sequences

30
RefSeq

2
UniProt

3
CCDS

CCDS25570.1

Ensembl

ENSMUSG00000020722 (Evidence)
NCBI Gene

12299

			Length	Strain/Species	Flank
genomic	12299	NCBI Gene Model \| MGI Sequence Detail	13259	C57BL/6J	± kb
transcript	NM_007582	RefSeq \| MGI Sequence Detail	1225	Not Specified
polypeptide	O70578	UniProt \| EBI \| MGI Sequence Detail	223	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004950 voltage-dependent calcium channel gamma-1 subunit

(term hierarchy)
InterPro Domains

IPR004031 PMP-22/EMP/MP20/Claudin

IPR005421 Voltage-dependent calcium channel, gamma-1 subunit

IPR008368 Voltage-dependent calcium channel, gamma subunit
GlyGen

O70578 2 sites

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All nucleic 28

Genomic 1

cDNA 26

Primer pair 1

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 9
Earliest

J:46501 Wissenbach U, et al., The structure of the murine calcium channel gamma-subunit gene and protein. Biol Chem. 1998 Jan;379(1):45-50
Latest

J:263025 Zoupa M, et al., Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429

TSS for Cacng1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111479	Chr11:107607397-107607408 (-)	-101 bp
Tssr111478	Chr11:107607370-107607383 (-)	-75 bp
Tssr111477	Chr11:107607343-107607354 (-)	-47 bp
Tssr111476	Chr11:107607282-107607340 (-)	-9 bp
Tssr111475	Chr11:107607276-107607279 (-)	24 bp
Tssr111474	Chr11:107607257-107607273 (-)	37 bp
Tssr111473	Chr11:107607239-107607246 (-)	59 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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