Bik MGI Mouse Gene Detail - MGI:1206591

Symbol

Bik
Name

BCL2-interacting killer
Synonyms

Biklk, Blk, Nbk

Feature Type

protein coding gene
IDs

MGI:1206591
NCBI Gene: 12124
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:83411063-83428835 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.40 cM
Mapping Data

3 experiments

SNPs within 2kb

644 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1206591	protein coding gene	Chr15:83410992-83428836 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022165	protein coding gene	Chr15:84232749-84252437 (+)
A/J	MGP_AJ_G0022124	protein coding gene	Chr15:81151183-81168942 (+)
AKR/J	MGP_AKRJ_G0022099	protein coding gene	Chr15:83513143-83530922 (+)
BALB/cJ	MGP_BALBcJ_G0022130	protein coding gene	Chr15:81293772-81311539 (+)
C3H/HeJ	MGP_C3HHeJ_G0021900	protein coding gene	Chr15:83471328-83489091 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022575	protein coding gene	Chr15:87483697-87503816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020100	protein coding gene	Chr15:77528272-77545688 (+)
CAST/EiJ	MGP_CASTEiJ_G0021422	protein coding gene	Chr15:84242057-84260109 (+)
CBA/J	MGP_CBAJ_G0021867	protein coding gene	Chr15:90250891-90269097 (+)
DBA/2J	MGP_DBA2J_G0021994	protein coding gene	Chr15:80634247-80652904 (+)
FVB/NJ	MGP_FVBNJ_G0021973	protein coding gene	Chr15:79679542-79697684 (+)
LP/J	MGP_LPJ_G0022065	protein coding gene	Chr15:84407019-84426821 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021993	protein coding gene	Chr15:95152446-95170215 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022590	protein coding gene	Chr15:83513862-83531576 (+)
PWK/PhJ	MGP_PWKPhJ_G0021163	protein coding gene	Chr15:80622421-80641466 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020997	protein coding gene	Chr15:83247125-83264979 (+)
WSB/EiJ	MGP_WSBEiJ_G0021471	protein coding gene	Chr15:84016250-84034308 (+)

Human Ortholog

BIK, BCL2 interacting killer

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BIK, BCL2 interacting killer
Synonyms

BIP1, BP4, NBK
Links

HGNC:1051

NCBI Gene ID: 638

neXtProt AC: NX_Q13323

UniProt: Q13323
Chr Location

22q13.2; chr22:43110750-43129712 (+) GRCh38

MGI Vertebrate Homology

Bik stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BIK
Gene Tree

Bik

Diseases

4 with human BIK associations

				Human Disease	Mouse Models
				ataxia telangiectasia IDs ataxia telangiectasia DOID:12704 MESH:D001260 NCI:C2887 OMIM:208900 UMLS_CUI:C0004135
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
23 phenotypes from multigenic genotypes
32 phenotype references

All Mutations and Alleles

26
Chemically induced (other)

1
Gene trapped

20
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Bik
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for a knock-out allele are viable and grossly normal with no detectable changes in hematopoiesis, lymphocyte susceptibility to various apoptotic stimuli, or endothelial cell apoptosis in hyaloid vessel regression.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

9
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

10
UniProt

4
CCDS

CCDS27703.1

Ensembl

ENSMUSG00000016758 (Evidence)
NCBI Gene

12124

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016758	Ensembl Gene Model \| MGI Sequence Detail	17773	C57BL/6J	± kb
transcript	ENSMUST00000016902	Ensembl \| MGI Sequence Detail	942	Not Applicable
polypeptide	ENSMUSP00000016902	Ensembl \| MGI Sequence Detail	150	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004747 Bcl-2-interacting killer

(term hierarchy)
InterPro Domains

IPR024579 Bcl-2-interacting killer

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All nucleic 17

Genomic 2

cDNA 13

Primer pair 1

Other 1

Microarray probesets 5

Summaries

All 64

Developmental Gene Expression 3

Diseases 1

Gene Ontology 7

Phenotypes 32
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:337771 El-Saafin F, et al., Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027

TSS for Bik:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132427	Chr15:83411055-83411075 (+)	2 bp
Tssr132428	Chr15:83411097-83411108 (+)	40 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24