Suz12 MGI Mouse Gene Detail - MGI:1261758 - SUZ12 polycomb repressive complex 2 subunit

Symbol

Suz12
Name

SUZ12 polycomb repressive complex 2 subunit
Synonyms

2610028O16Rik, D11Ertd530e, mKIAA0160

Feature Type

protein coding gene
IDs

MGI:1261758
NCBI Gene: 52615
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:79883932-79924949 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 47.36 cM
Mapping Data

4 experiments

SNPs within 2kb

1130 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261758	protein coding gene	Chr11:79883932-79924949 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018803	protein coding gene	Chr11:81122369-81167757 (+)
A/J	MGP_AJ_G0018770	protein coding gene	Chr11:78009266-78053563 (+)
AKR/J	MGP_AKRJ_G0018740	protein coding gene	Chr11:80358062-80401307 (+)
BALB/cJ	MGP_BALBcJ_G0018743	protein coding gene	Chr11:78396411-78442072 (+)
C3H/HeJ	MGP_C3HHeJ_G0018557	protein coding gene	Chr11:80402627-80448670 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019195	protein coding gene	Chr11:83609731-83656438 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016829	protein coding gene	Chr11:74944194-74988426 (+)
CAST/EiJ	MGP_CASTEiJ_G0018112	protein coding gene	Chr11:80875776-80921485 (+)
CBA/J	MGP_CBAJ_G0018528	protein coding gene	Chr11:87261494-87306702 (+)
DBA/2J	MGP_DBA2J_G0018636	protein coding gene	Chr11:77562590-77609650 (+)
FVB/NJ	MGP_FVBNJ_G0018625	protein coding gene	Chr11:77136851-77180088 (+)
LP/J	MGP_LPJ_G0018706	protein coding gene	Chr11:81637559-81690776 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018652	protein coding gene	Chr11:87543561-87591645 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019235	protein coding gene	Chr11:80599287-80647359 (+)
PWK/PhJ	MGP_PWKPhJ_G0017882	protein coding gene	Chr11:78370683-78415053 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017673	protein coding gene	Chr11:80198807-80238048 (+)
WSB/EiJ	MGP_WSBEiJ_G0018164	protein coding gene	Chr11:80435869-80480846 (+)

Human Ortholog

SUZ12, SUZ12 polycomb repressive complex 2 subunit

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUZ12, SUZ12 polycomb repressive complex 2 subunit
Synonyms

CHET9, IMMAS, JJAZ1
Links

HGNC:17101

NCBI Gene ID: 23512

neXtProt AC: NX_Q15022

UniProt: Q15022
Chr Location

17q11.2; chr17:31937007-32001038 (+) GRCh38

MGI Vertebrate Homology

Suz12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SUZ12
Gene Tree

Suz12

Diseases

1 with human SUZ12 associations

				Human Disease	Mouse Models
				renal Wilms' tumor IDs renal Wilms' tumor DOID:5176 NCI:C6951 UMLS_CUI:C1335062

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

38 phenotypes from 4 alleles in 5 genetic backgrounds
26 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

21
Targeted

10
Genomic Mutations

2 involving Suz12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis. Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance.

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All GO Annotations

58
GO References

36

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

915
Tissues

96
cDNA Data

23
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SUZ12

Xenbase suz12

ZFIN suz12a, suz12b

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All Sequences

70
RefSeq

4
UniProt

7
CCDS

CCDS25125.1, CCDS48860.1

Ensembl

ENSMUSG00000017548 (Evidence)
NCBI Gene

52615

			Length	Strain/Species	Flank
genomic	52615	NCBI Gene Model \| MGI Sequence Detail	41018	C57BL/6J	± kb
transcript	NM_199196	RefSeq \| MGI Sequence Detail	4449	ZRU/MplStud
polypeptide	Q80U70	UniProt \| EBI \| MGI Sequence Detail	741	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000015848 polycomb protein SUZ12

(term hierarchy)
InterPro Domains

IPR019135 Polycomb protein, VEFS-Box

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All nucleic 32

cDNA 24

Primer pair 7

Other 1

Microarray probesets 10

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MGI:1922065, MGI:2144085, MGI:2144379, MGI:2144551

Summaries

All 138

Developmental Gene Expression 34

Gene Ontology 36

Phenotypes 37
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346895 Guo P, et al., A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis. Elife. 2024 Feb 12;13

TSS for Suz12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103473	Chr11:79883888-79883948 (+)	-14 bp
Tssr103474	Chr11:79883969-79883978 (+)	42 bp
Tssr103475	Chr11:79884018-79884058 (+)	106 bp
Tssr103476	Chr11:79890067-79890071 (+)	6,137 bp
Tssr103477	Chr11:79903508-79903515 (+)	19,580 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24