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Lsamp Gene Detail
Summary
  • Symbol
    Lsamp
  • Name
    limbic system-associated membrane protein
  • Synonyms
    B130007O04Rik, D930023J12Rik, Lam, Lamp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261760
    NCBI Gene: 268890
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:41353220-42002042 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 28.26 cM, cytoband B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15093 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261760
 protein coding gene Chr16:39804674-42002042 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022825
 protein coding gene Chr16:38574297-40855873 (+)
A/J MGP_AJ_G0022790
 protein coding gene Chr16:36674691-38950738 (+)
AKR/J MGP_AKRJ_G0022762
 protein coding gene Chr16:38064634-40276144 (+)
BALB/cJ MGP_BALBcJ_G0022791
 protein coding gene Chr16:36782673-38961701 (+)
C3H/HeJ MGP_C3HHeJ_G0022555
 protein coding gene Chr16:38162200-40424065 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023238
 protein coding gene Chr16:39458768-41791443 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020753
 protein coding gene Chr16:37002192-39116409 (+)
CAST/EiJ MGP_CASTEiJ_G0022081
 protein coding gene Chr16:38326513-40629698 (+)
CBA/J MGP_CBAJ_G0022526
 protein coding gene Chr16:41177989-43580173 (+)
DBA/2J MGP_DBA2J_G0022658
 protein coding gene Chr16:36537442-38723993 (+)
FVB/NJ MGP_FVBNJ_G0022633
 protein coding gene Chr16:36540820-38710328 (+)
LP/J MGP_LPJ_G0022726
 protein coding gene Chr16:38206761-40542482 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022652
 protein coding gene Chr16:40357866-42914037 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023253
 protein coding gene Chr16:38001898-40265117 (+)
PWK/PhJ MGP_PWKPhJ_G0021821
 protein coding gene Chr16:36952735-39124411 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021652
 protein coding gene Chr16:37897335-40181237 (+)
WSB/EiJ MGP_WSBEiJ_G0022125
 protein coding gene Chr16:38089293-40370719 (+)



Homology
more
  • Human Ortholog
    LSAMP, limbic system associated membrane protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LSAMP, limbic system associated membrane protein
  • Synonyms
    IGLON3, LAMP
  • Links
    NCBI Gene ID: 4045
    neXtProt AC: NX_Q13449
    UniProt: Q13449

  • Chr Location
    3q13.31; chr3:115802374-117997592 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene are hyperresponsive to novel environments. Mice homozygous for another knock-out allele exhibit reduced barbering, whisker trimming, anxiety, dominance, and aggression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    248
  • cDNA Data
    15
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061080 Ensembl Gene Model | MGI Sequence Detail 648823 C57BL/6J ±  kb
    transcript ENSMUST00000078873 Ensembl | MGI Sequence Detail 2951 Not Applicable  
    polypeptide ENSMUSP00000077913 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 15
      Primer pair 1
      Other 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1095398, MGI:2146612, MGI:2442078, MGI:3041227
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 17
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:41462 Zhang JH, et al., Dynamic expression suggests multiple roles of the eph family receptor brain-specific kinase (Bsk) during mouse neurogenesis. Brain Res Mol Brain Res. 1997 Jul;47(1-2):202-14
    • Latest
      J:354852 Singh K, et al., The IgLON family of cell adhesion molecules expressed in developing neural circuits ensure the proper functioning of the sensory system in mice. Sci Rep. 2024 Sep 30;14(1):22593
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory