About   Help   FAQ
Mcpt8 Gene Detail
Summary
  • Symbol
    Mcpt8
  • Name
    mast cell protease 8
  • Synonyms
    MMCP-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261780
    NCBI Gene: 17231
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56319623-56322730 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261780
 protein coding gene Chr14:56319620-56322951 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021383
 protein coding gene Chr14:50149866-50152911 (-)
A/J MGP_AJ_G0021342
 protein coding gene Chr14:49161052-49164102 (-)
AKR/J MGP_AKRJ_G0021318
 protein coding gene Chr14:50918646-50921696 (-)
BALB/cJ MGP_BALBcJ_G0021345
 protein coding gene Chr14:49131620-49134670 (-)
C3H/HeJ MGP_C3HHeJ_G0021126
 protein coding gene Chr14:50601396-50604446 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021785
 protein coding gene Chr14:52677485-52680535 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019327
 protein coding gene Chr14:47375179-47378204 (-)
CAST/EiJ MGP_CASTEiJ_G0020645
 protein coding gene Chr14:46882405-46885457 (-)
CBA/J MGP_CBAJ_G0021093
 protein coding gene Chr14:54219676-54222706 (-)
DBA/2J MGP_DBA2J_G0021213
 protein coding gene Chr14:48884883-48887897 (-)
FVB/NJ MGP_FVBNJ_G0021196
 protein coding gene Chr14:48300259-48303298 (-)
LP/J MGP_LPJ_G0021288
 protein coding gene Chr14:51200334-51203379 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021220
 protein coding gene Chr14:53583989-53587028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021811
 protein coding gene Chr14:50104051-50107101 (-)
PWK/PhJ MGP_PWKPhJ_G0020389
 protein coding gene Chr14:45407883-45410973 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020219
 protein coding gene Chr14:46158118-46161133 (-)
WSB/EiJ MGP_WSBEiJ_G0020698
 protein coding gene Chr14:50362399-50365433 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    44 phenotype references
Mice homozygous for a knock-in mutation that allows diphtheria toxin-mediated basophil depletion before the second tick infestation exhibit loss of acquired tick resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022157 Ensembl Gene Model | MGI Sequence Detail 3108 C57BL/6J ±  kb
transcript ENSMUST00000015594 Ensembl | MGI Sequence Detail 836 Not Applicable  
polypeptide ENSMUSP00000015594 Ensembl | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145855
References
more
  • Summaries
    All 73
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 44
  • Earliest
    J:46663 Lutzelschwab C, et al., Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J Immunol. 1998 Mar;28(3):1022-33
  • Latest
    J:351164 Park J, et al., The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function. J Allergy Clin Immunol. 2024 Jan;153(1):132-145
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory