Palm MGI Mouse Gene Detail - MGI:1261814

Symbol

Palm
Name

paralemmin
Synonyms

mKIAA0270

Feature Type

protein coding gene
IDs

MGI:1261814
NCBI Gene: 18483
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:79629406-79656730 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

667 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261814	protein coding gene	Chr10:79629406-79656749 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017461	protein coding gene	Chr10:80338961-80371306 (+)
A/J	MGP_AJ_G0017439	protein coding gene	Chr10:77546618-77574963 (+)
AKR/J	MGP_AKRJ_G0017400	protein coding gene	Chr10:79654203-79683985 (+)
BALB/cJ	MGP_BALBcJ_G0017401	protein coding gene	Chr10:77773528-77801410 (+)
C3H/HeJ	MGP_C3HHeJ_G0017224	protein coding gene	Chr10:79763486-79790814 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017855	protein coding gene	Chr10:83112478-83143371 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015543	protein coding gene	Chr10:73773548-73801659 (+)
CAST/EiJ	MGP_CASTEiJ_G0016791	protein coding gene	Chr10:79943538-79974778 (+)
CBA/J	MGP_CBAJ_G0017196	protein coding gene	Chr10:86337382-86367102 (+)
DBA/2J	MGP_DBA2J_G0017302	protein coding gene	Chr10:76762022-76789611 (+)
FVB/NJ	MGP_FVBNJ_G0017296	protein coding gene	Chr10:75935593-75968043 (+)
LP/J	MGP_LPJ_G0017373	protein coding gene	Chr10:80822334-80850917 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017322	protein coding gene	Chr10:88318581-88347419 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017896	protein coding gene	Chr10:79635037-79669852 (+)
PWK/PhJ	MGP_PWKPhJ_G0016572	protein coding gene	Chr10:76622088-76649756 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016361	protein coding gene	Chr10:78613892-78641528 (+)
WSB/EiJ	MGP_WSBEiJ_G0016851	protein coding gene	Chr10:79663733-79692657 (+)

Human Ortholog

PALM, paralemmin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PALM, paralemmin
Synonyms

PALM1
Links

HGNC:8594

NCBI Gene ID: 5064

neXtProt AC: NX_O75781

UniProt: O75781
Chr Location

19p13.3; chr19:708935-748329 (+) GRCh38

MGI Vertebrate Homology

Palm stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PALM
Gene Tree

Palm

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Targeted

5
Genomic Mutations

1 involving Palm
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, healthy, fertile and overtly normal, and show normal development and physiological function of the lymphatic system.

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All GO Annotations

42
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

46
cDNA Data

101
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase palm

ZFIN palm1a

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All Sequences

60
RefSeq

10
UniProt

9
CCDS

CCDS23991.1, CCDS48621.1

Ensembl

ENSMUSG00000035863 (Evidence)
NCBI Gene

18483

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035863	Ensembl Gene Model \| MGI Sequence Detail	27325	C57BL/6J	± kb
transcript	ENSMUST00000046945	Ensembl \| MGI Sequence Detail	2651	Not Applicable
polypeptide	ENSMUSP00000040596	Ensembl \| MGI Sequence Detail	383	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000012249 paralemmin

(term hierarchy)
InterPro Domains

IPR004965 Paralemmin
GlyGen

Q9Z0P4 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 104

cDNA 103

Primer pair 1

Microarray probesets 4

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Palm:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94392	Chr10:79629156-79629168 (+)	-244 bp
Tssr94393	Chr10:79629387-79629455 (+)	15 bp
Tssr94394	Chr10:79629492-79629507 (+)	94 bp
Tssr94395	Chr10:79629511-79629555 (+)	127 bp
Tssr94396	Chr10:79641820-79641839 (+)	12,424 bp
Tssr94397	Chr10:79641846-79641865 (+)	12,450 bp
Tssr94398	Chr10:79643096-79643111 (+)	13,698 bp
Tssr94399	Chr10:79643116-79643154 (+)	13,729 bp
Tssr94400	Chr10:79650420-79650457 (+)	21,033 bp
Tssr94401	Chr10:79650500-79650518 (+)	21,103 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24