Wnt2b MGI Mouse Gene Detail - MGI:1261834 - wingless-type MMTV integration site family, member 2B

Symbol

Wnt2b
Name

wingless-type MMTV integration site family, member 2B
Synonyms

Wnt13

Feature Type

protein coding gene
IDs

MGI:1261834
NCBI Gene: 22414
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:104852588-104869237 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 45.88 cM
Mapping Data

2 experiments

SNPs within 2kb

436 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261834	protein coding gene	Chr3:104852121-104869237 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027714	protein coding gene	Chr3:106284939-106301868 (-)
A/J	MGP_AJ_G0027674	protein coding gene	Chr3:102887229-102904201 (-)
AKR/J	MGP_AKRJ_G0027639	protein coding gene	Chr3:105427338-105443985 (-)
BALB/cJ	MGP_BALBcJ_G0027686	protein coding gene	Chr3:102675148-102691899 (-)
C3H/HeJ	MGP_C3HHeJ_G0027416	protein coding gene	Chr3:105800111-105817916 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028130	protein coding gene	Chr3:110245775-110263131 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025470	protein coding gene	Chr3:98996386-99013314 (-)
CAST/EiJ	MGP_CASTEiJ_G0026872	protein coding gene	Chr3:104915667-104933575 (-)
CBA/J	MGP_CBAJ_G0027391	protein coding gene	Chr3:114003068-114020014 (-)
DBA/2J	MGP_DBA2J_G0027533	protein coding gene	Chr3:102140219-102156868 (-)
FVB/NJ	MGP_FVBNJ_G0027501	protein coding gene	Chr3:100066026-100082929 (-)
LP/J	MGP_LPJ_G0027640	protein coding gene	Chr3:107691357-107708277 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027531	protein coding gene	Chr3:120121279-120137933 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028185	protein coding gene	Chr3:104978074-104994501 (-)
PWK/PhJ	MGP_PWKPhJ_G0026598	protein coding gene	Chr3:101919043-101935800 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026419	protein coding gene	Chr3:103016488-103033217 (-)
WSB/EiJ	MGP_WSBEiJ_G0026952	protein coding gene	Chr3:105562632-105579642 (-)

Human Ortholog

WNT2B, Wnt family member 2B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WNT2B, Wnt family member 2B
Synonyms

WNT13
Links

HGNC:12781

NCBI Gene ID: 7482

neXtProt AC: NX_Q93097

UniProt: Q93097
Chr Location

1p13.2; chr1:112466541-112530165 (+) GRCh38

MGI Vertebrate Homology

Wnt2b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WNT2B
Gene Tree

Wnt2b

Diseases

1 with human WNT2B associations

				Human Disease	Mouse Models
				congenital diarrhea IDs congenital diarrhea DOID:0060774 OMIM:PS214700

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Wnt2b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit no discernable phenotype.

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All GO Annotations

25
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1397
Tissues

449
cDNA Data

18
Literature Summary

153

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WNT2B

Xenbase wnt2b

ZFIN wnt2ba, wnt2bb

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS17706.1

Ensembl

ENSMUSG00000027840 (Evidence)
NCBI Gene

22414

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027840	Ensembl Gene Model \| MGI Sequence Detail	16650	C57BL/6J	± kb
transcript	ENSMUST00000029429	Ensembl \| MGI Sequence Detail	3318	Not Applicable
polypeptide	ENSMUSP00000029429	Ensembl \| MGI Sequence Detail	389	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017441 protein Wnt-2b

(term hierarchy)
InterPro Domains

IPR005817 Wnt

IPR009140 Wnt-2 protein

IPR043158 Wnt, C-terminal domain

IPR018161 Wnt protein, conserved site
GlyGen

O70283 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 49

Genomic 1

cDNA 20

Primer pair 15

Other 13

Microarray probesets 3

Summaries

All 198

Developmental Gene Expression 153

Diseases 1

Gene Ontology 10

Phenotypes 19
Earliest

J:47698 Zakin LD, et al., Structure and expression of Wnt13, a novel mouse Wnt2 related gene. Mech Dev. 1998 Apr;73(1):107-16
Latest

J:357576 Takahashi M, et al., Lineage tracing using Wnt2b-2A-CreERT2 knock-in mice reveals the contributions of Wnt2b-expressing cells to novel subpopulations of mesothelial/epicardial cell lineages during mouse development. Genes Cells. 2024 Aug 7;

TSS for Wnt2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34911	Chr3:104869050-104869061 (-)	181 bp
Tssr34910	Chr3:104869011-104869044 (-)	209 bp
Tssr34909	Chr3:104868984-104869002 (-)	244 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24